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Quantitative Analysis
Study Course Description
Course Description Statuss:Approved
Course Description Version:11.00
Study Course Accepted:20.08.2024 08:38:12
| Study Course Information | |||||||||
| Course Code: | FKK_003 | LQF level: | Level 7 | ||||||
| Credit Points: | 4.00 | ECTS: | 6.00 | ||||||
| Branch of Science: | Chemistry; Analytical Chemistry | Target Audience: | Pharmacy | ||||||
| Study Course Supervisor | |||||||||
| Course Supervisor: | Aina Semjonova | ||||||||
| Study Course Implementer | |||||||||
| Structural Unit: | Department of Pharmaceutical Chemistry | ||||||||
| The Head of Structural Unit: | |||||||||
| Contacts: | Riga, 16 Dzirciema Street, Block A, 5th floor, Room No. 502, farmkk rsu[pnkts]lv, +371 67061544 | ||||||||
| Study Course Planning | |||||||||
| Full-Time - Semester No.1 | |||||||||
| Lectures (count) | 0 | Lecture Length (academic hours) | 0 | Total Contact Hours of Lectures | 0 | ||||
| Classes (count) | 17 | Class Length (academic hours) | 4 | Total Contact Hours of Classes | 68 | ||||
| Total Contact Hours | 68 | ||||||||
| Study course description | |||||||||
| Preliminary Knowledge: | Inorganic chemistry and Physics within the scope of the Pharmacy program. Organic and Physical Chemistry within the scope of the Secondary school. | ||||||||
| Objective: | To provide the opportunity to acquire the quantitative chemical and simple instrumental analysis methods widely used in pharmaceutical analysis, to gain insight into their application in practice and to acquire basic skills for work in the laboratory. | ||||||||
| Topic Layout (Full-Time) | |||||||||
| No. | Topic | Type of Implementation | Number | Venue | |||||
| 1 | Introductory lesson. Workshop: introduction to quantitative analysis, measuring cups used in a laboratory, theoretical substantiation of titrimetry, and calculations. Laboratory work: Measuring the volume of laboratory glassware | Classes | 1.00 | laboratory | |||||
| 2 | Workshop: calculations in direct titration. Laboratory work: acidimetry. | Classes | 1.00 | laboratory | |||||
| 3 | Workshop: calculations in reverse titration. Laboratory work: alkalimetry. | Classes | 1.00 | laboratory | |||||
| 4 | Laboratory works: titration of weak bases in non-aqueous media; complexonometry | Classes | 1.00 | laboratory | |||||
| 5 | Colloquium: Fundamentals of quantitative analysis and titrimetry, protolitometry in aqueous and non-aqueous media, complexometry. | Classes | 1.00 | laboratory | |||||
| 6 | Laboratory work: argentometry. | Classes | 1.00 | laboratory | |||||
| 7 | Workshop: calculations in replacement titration and control titration Laboratory work: permanganatometry | Classes | 1.00 | laboratory | |||||
| 8 | Laboratory work: iodometry. | Classes | 1.00 | laboratory | |||||
| 9 | Laboratory works: bromatometry, bromometry | Classes | 1.00 | laboratory | |||||
| 10 | Workshop: calculations in gravimetric methods Laboratory work: nitritometry. | Classes | 1.00 | auditorium | |||||
| 11 | Colloquium: sedimetry, oxidimetry, gravimetry. | Classes | 1.00 | laboratory | |||||
| 12 | Workshop: calculation in refractometry Laboratory work: potentiometry, refractometry | Classes | 1.00 | laboratory | |||||
| 13 | Workshop: calculations in spectrophotometry Laboratory work: spectrophotometry | Classes | 1.00 | laboratory | |||||
| 14 | Workshop: calcualtions in chromatography Laboratory work: high-performance liquid chromatography (HPLC) | Classes | 1.00 | laboratory | |||||
| 15 | Workshop: group presentations on methods of instrumental analysis | Classes | 1.00 | laboratory | |||||
| 16 | Colloquium: methods of instrumental analysis. | Classes | 1.00 | laboratory | |||||
| 17 | Presentation of independent work - analysis of a selected medicinal substance. | Classes | 1.00 | laboratory | |||||
| Assessment | |||||||||
| Unaided Work: | • Individual practical work in the laboratory of analytical chemistry and writing protocols; • Literature research; • Solving calculation tasks according to the course topics; • Preparation for colloquiums and tests; • Creating a description of a complicated instrumental analysis method and analysis of a scientific article by working in groups; • Making a presentation on the methods of analysis of the chosen medicinal substance. | ||||||||
| Assessment Criteria: | • Colloquium grades, which are formed by the average value of the marks of the theory and calculation task parts; • Evaluation of the scientific article analysis according to the established criteria; • Evaluation of the independent work presentation, which includes a summary of the methods of qualitative and quantitative analysis of the medicinal substance; • Evaluation of the accuracy of medicinal substances quantification during practical work and participation in seminars; • Written examination on nature, application possibilities, and calculations of quantitative analysis methods, which is structurally identical to the colloquium. The final grade of the course is calculated as follows: 50% exam mark + 25% average colloquium mark + 5% article analysis grade + 10% presentation grade + 10% average grade of participation in seminars and laboratory work results. | ||||||||
| Final Examination (Full-Time): | Exam (Written) | ||||||||
| Final Examination (Part-Time): | |||||||||
| Learning Outcomes | |||||||||
| Knowledge: | Upon successful completion of the study course students will be able to: • describe the nature of the most important titrimetric and instrumental methods; • understand the applicability of quantitative analysis methods. | ||||||||
| Skills: | As a result of the study course students: • will be able to choose methods of chemical and instrumental analysis appropriate to the chemical and physical properties of the substances; • will be able to apply them in practice in drug substance analysis; • will be able to calculate and evaluate the results of the analysis; • will be able to work properly with laboratory glassware and various equipment used in analytical chemistry. | ||||||||
| Competencies: | Understanding the basic principles of quantitative substance analysis and detection. Finding relationship between theoretical calculation and practical sample and reactant properties. Possibility of evaluating errors on the results obtained. | ||||||||
| Bibliography | |||||||||
| No. | Reference | ||||||||
| Required Reading | |||||||||
| 1 | G. D. Christian, P. K. Dasgupta, K. A. Schug. Analytical Chemistry. 7th Edition. John Wiley & Sons, Inc., USA, 2020. | ||||||||
| Additional Reading | |||||||||
| 1 | D. C. Harris, C. A. Lucy. Quantitative Chemical Analysis. 10th edition. W. H. Freeman, New-York, 2020. | ||||||||
| 2 | D. A. Skoog, D. M. West, F. James Holler, S. R. Crouch. Fundamentals of Analytical Chemistry. 10th edition, Mary Finch, USA, 2022. | ||||||||
| Other Information Sources | |||||||||
| 1 | E. Jansons. Analītiskās ķīmijas teorētiskie pamati. Rīga, 2006. | ||||||||
| 2 | Council of Europe, European Pharmacopoeia. 11th edition. Strasbourg: Council of Europe, 2024. | ||||||||
