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Physical Pharmacy

Study Course Description

Course Description Statuss:Approved
Course Description Version:1.00
Study Course Accepted:20.03.2024 16:34:03
Study Course Information
Course Code:FKK_046LQF level:Level 7
Credit Points:2.67ECTS:4.00
Branch of Science:Basic Sciences of Medicine, including PharmacyTarget Audience:Pharmacy
Study Course Supervisor
Course Supervisor:Liāna Orola
Study Course Implementer
Structural Unit:Department of Pharmaceutical Chemistry
The Head of Structural Unit:
Contacts:Riga, 16 Dzirciema Street, Block A, 5th floor, Room No. 502.kab., farmkkatrsu[pnkts]lv, +371 67061544
Study Course Planning
Full-Time - Semester No.1
Lectures (count)6Lecture Length (academic hours)2Total Contact Hours of Lectures12
Classes (count)9Class Length (academic hours)4Total Contact Hours of Classes36
Total Contact Hours48
Part-Time - Semester No.1
Lectures (count)6Lecture Length (academic hours)4Total Contact Hours of Lectures24
Classes (count)6Class Length (academic hours)4Total Contact Hours of Classes24
Total Contact Hours48
Study course description
Preliminary Knowledge:
Inorganic, organic and analytical chemistry, desirable knowledge of physics and advanced mathematics.
Objective:
The aim of the course is to provide knowledge of the theoretical and practical principles of physical pharmacy. The tasks of the course are to develop skills to use knowledge of physico-chemical processes and phenomena in pharmacy, to acquire methods of determination of physico-chemical parameters of substances, to interpret acquired data, to improve presentation skills, as well as skills to work with scientific information sources. The course deals with thermodynamics, physical states of substances, phases and their transitions, kinetics, physico-chemical properties of substances in solutions, as well as colloidal systems.
Topic Layout (Full-Time)
No.TopicType of ImplementationNumberVenue
1Thermodynamics. Phases and their transitions. Gases and volatiles.Lectures1.00auditorium
2Introductory lesson. Safe working methods. Entrance colloquium (exercises on the forms of concentration).Classes1.00laboratory
3Solids.Lectures1.00auditorium
4Laboratory work: Calorimetry.Classes1.00laboratory
5Physico-chemical properties of drug substances in solutions.Lectures1.00auditorium
6Colloquium: Thermodynamics, phases and their transitions, gases and volatiles, solids.Classes1.00laboratory
7Solubility and Dissolution.Lectures1.00auditorium
8Laboratory work: Determination of acid dissociation constant.Classes1.00laboratory
9Chemical kinetics. Chemical stability of the drug substance.Lectures1.00auditorium
10Laboratory work: Determination of solubility.Classes1.00laboratory
11Colloidal systems. Surfactants.Lectures1.00auditorium
12Colloquium: Physico-chemical properties of drug substances in solutions, solubility and dissolution.Classes1.00laboratory
13Laboratory work: Buffers.Classes1.00laboratory
14Laboratory work: Emulsions.Classes1.00laboratory
15Colloquium: Chemical kinetics, chemical stability of drug substances, colloidal systems, surfactants.Classes1.00laboratory
Topic Layout (Part-Time)
No.TopicType of ImplementationNumberVenue
1Thermodynamics. Phases and their transitions. Gases and volatiles.Lectures1.00laboratory
2Introductory lesson. Safe working methods. Entrance colloquium (exercises on the forms of concentration).Classes0.50laboratory
3Solids.Lectures1.00auditorium
4Laboratory work: Calorimetry.Classes0.50laboratory
5Physico-chemical properties of drug substances in solutions.Lectures1.00auditorium
6Colloquium: Thermodynamics, phases and their transitions, gases and volatiles, solids.Classes1.00laboratory
7Solubility and Dissolution.Lectures1.00auditorium
8Laboratory work: Determination of acid dissociation constant.Classes0.50laboratory
9Chemical kinetics. Chemical stability of the drug substance.Lectures1.00auditorium
10Laboratory work: Determination of solubility.Classes0.50laboratory
11Colloidal systems. Surfactants.Lectures1.00auditorium
12Colloquium: Physico-chemical properties of drug substances in solutions, solubility and dissolution.Classes1.00laboratory
13Laboratory work: Buffers.Classes0.50laboratory
14Laboratory work: Emulsions.Classes1.00laboratory
15Colloquium: Chemical kinetics, chemical stability of drug substances, colloidal systems, surfactants.Classes0.50laboratory
Assessment
Unaided Work:
Students have to prepare themselves for laboratory work (theoretical basis of the work, theoretical tasks). Students need to read relevant sections of compulsory literature in addition to lecture materials. Student does independent work outside of study time. It is recommended to fill in the study course survey, evaluating the existing course content and creating proposals for updating the course.
Assessment Criteria:
Theoretical knowledge and ability to apply theoretical knowledge in practical tasks will be assessed. Student attitude (attendance, interest) will be evaluated. The final grade of the study course consists of the average mark of the colloquium (50%) and the mark of the exam (50%).
Final Examination (Full-Time):Exam (Written)
Final Examination (Part-Time):Exam (Written)
Learning Outcomes
Knowledge:As a result of the course students will acquire knowledge of basic principles of drug substance thermodynamics and kinetics, drug state, other phase, physicochemical properties of solutions as well as colloidal systems of drug substances.
Skills:Using the acquired knowledge students will be able to characterize the physico-chemical properties of drug substances and will be able to solve problems related to physical pharmacy topics, eg drug substance stability, solubility, phase others, drug substance formulation. Students will acquire the skills to interpret the data obtained from the analysis, as well as to search and use information sources, collaborate in a group and present the results.
Competencies:Using the acquired knowledge and skills will be able to apply appropriate physico-chemical methods for successful research and characterization of drug substances.
Bibliography
No.Reference
Required Reading
1A. T. Florence., D. Attwood. Physicochemical Principles of Pharmacy: In Manufacture, Formulation and Clinical Use. 6th ed. London: Pharmaceutical Press, 2016 (e-grāmata, pieejama ProQuest Ebook Central e-grāmatu datubāzē).
2S. C. Fox. Pharmaceutics. 1st ed. London: Pharmaceutical Press, 2014 (e-grāmata, pieejama ProQuest Ebook Central e-grāmatu datubāzē).
3K. A. Connors, S. Mecozzi. Thermodynamics of Pharmaceutical Systems: An Introduction to Theory and Applications. 2nd ed. John Wiley & Sons, 2010 (akceptējams izdevums)
4B. Linder. Elementary Physical Chemistry. World Scientific Publishing Co Pte Ltd, 2010 (e-grāmata, pieejama ProQuest Ebook Central e-grāmatu datubāzē). (akceptējams izdevums)
5G. Zografi, X. Chen, S. R. Byrn. Solid-State Properties of Pharmaceutical Materials. John Wiley & Sons, 2017 (e-grāmata, pieejama ProQuest Ebook Central e-grāmatu datubāzē).
6G. M. Kontogeorgis, S. Kiil. Introduction to Applied Colloid and Surface Chemistry. Wiley, 2016 (e-grāmata, pieejama ProQuest Ebook Central e-grāmatu datubāzē).
Additional Reading
1P. Atkins, J. de Paula. Atkins' physical chemistry. 9th ed. Oxford; New York: Oxford University Press, 2010, 972 p.
2Student's solutions manual to accompany Atkins' physical chemistry, ninth edition / Charles Trapp, Marshall Cady and Carmen Giunta. New York: W. H. Freeman and Company, 2010. viii, 599 lpp.
3CRC handbook of chemistry and physics: a ready-reference book of chemical and physical data. 91st ed. / editor-in-chief, W. M. Haynes; associate editor, David R. Lide. Boca Raton: CRC Press/Taylor & Francis Group, 2019. [2260] lpp.
4Physical chemistry: principles and applications in biological sciences / Ignacio Tinoco, Jr. ... [et al.]. 4th ed. Upper Saddle River, N.J.: Prentice Hall, c2002. xix, 740 lpp.
5Y. Qiu, Y. Chen, G. G. Z. Zhang, W. Porter, L. Liu, V. Rao, W. Porter. Developing Solid Oral Dosage Forms: Pharmaceutical Theory and Practice. 1st ed. Elsevier Science & Technology, 2017 (e-grāmata, pieejama ProQuest Ebook Central e-grāmatu datubāzē).