Medical Biochemistry

Study Course Description

Course Description Statuss:Approved

Course Description Version:9.00

Study Course Accepted:06.08.2024 11:03:18

Study Course Information
Course Code:		CFUBK_047		LQF level:		Level 7
Credit Points:		5.00		ECTS:		7.50
Branch of Science:		Clinical Medicine; Medical Biochemistry		Target Audience:		Pharmacy
Study Course Supervisor
Course Supervisor:		Ināra Nokalna
Study Course Implementer
Structural Unit:		Department of Human Physiology and Biochemistry
The Head of Structural Unit:
Contacts:		Riga, 16 Dzirciema Street, cfbkrsu[pnkts]lv, +371 67061550
Study Course Planning
Full-Time - Semester No.1
Lectures (count)		12	Lecture Length (academic hours)		2	Total Contact Hours of Lectures		24
Classes (count)		12	Class Length (academic hours)		2	Total Contact Hours of Classes		24
Total Contact Hours								48
Full-Time - Semester No.2
Lectures (count)		7	Lecture Length (academic hours)		2	Total Contact Hours of Lectures		14
Classes (count)		9	Class Length (academic hours)		2	Total Contact Hours of Classes		18
Total Contact Hours								32
Part-Time - Semester No.1
Lectures (count)		8	Lecture Length (academic hours)		2	Total Contact Hours of Lectures		16
Classes (count)		8	Class Length (academic hours)		2	Total Contact Hours of Classes		16
Total Contact Hours								32
Study course description
Preliminary Knowledge:
General and organic chemistry, biology in high school and FF II course program level.
Objective:
1. To promote the acquisition of knowledge about the human body's chemical structure 2. Learn the metabolism, the opportunities of regulation and changes in different situations 3. Learn the possible routes of drugs, their inactivation processes
Topic Layout (Full-Time)
No.	Topic			Type of Implementation		Number	Venue
1	Introduction to biochemistry. Biochemistry and pharmaceuticals. Proteins			Lectures		1.00	auditorium
2	Simple proteins. Compound proteins. Chromoproteins. Enzymes			Lectures		2.00	auditorium
3	Enzymes			Lectures		2.00	auditorium
4	Vitamins – water and fat soluble. Vitamins and coenzymes in medicine			Lectures		1.00	auditorium
5	Metabolism. Central catabolic pathways. Krebs cycle ATP formation pathways. Oxidants and antioxidative system			Lectures		3.00	auditorium
6	Carbohydrate metabolism			Lectures		3.00	auditorium
7	Lipid metabolism			Lectures		2.00	auditorium
8	Amino acid metabolism			Lectures		3.00	auditorium
9	Hormonal regulation principles of metabolism. Metabolism of xenobiotics			Lectures		2.00	auditorium
10	Most important functional groups in biochemistry and their properties			Classes		1.00	laboratory
11	Proof reactions of amino acids. Proof reactions of amino acids. Protein quantitative determination techniques. Protein quantitative determination techniques. Chromoproteins. Hemoglobin forms of spectroscopy			Classes		1.00	laboratory
12	Proof of enzyme specificity. Enzymatic reaction dependence on T ° and pH			Classes		1.00	laboratory
13	Enzyme activity detection methods			Classes		1.00	laboratory
14	Enzyme activators and inhibitors			Classes		1.00	laboratory
15	COLLOQUIUM: Proteins. Enzymes			Classes		1.00	laboratory
16	Proof of water-soluble vitamins			Classes		1.00	laboratory
17	Nutrient digestive process			Classes		1.00	laboratory
18	Protein, fat and carbohydrate digestion			Classes		1.00	laboratory
19	COLLOQUIUM: Vitamins			Classes		1.00	laboratory
20	Seminar: Bioenergy. Antioxidant system. SDH demonstration. Hydroperoxidases			Classes		1.00	laboratory
21	COLLOQUIUM: Bioenergetics			Classes		1.00	laboratory
22	Seminar: Glycolytic pathway of glucose metabolism. Oxidative decarboxylation of PVA. Gluconeogenesis. Seminar: Glycogen synthesis and degradation process. Non-energy pathways of glucose metabolism Lab work: Lactate proof in muscles			Classes		2.00	laboratory
23	Colloquium: Glucose metabolism			Classes		1.00	laboratory
24	Seminar: Triacylglycerol metabolism. Fatty acid metabolism. Ketones. Laboratory work: Demonstration of ketones			Classes		1.00	laboratory
25	Seminar: Cholesterol. Synthesis of phospholipids and fats. Lab. work: Determination of cholesterol in the analysis			Classes		1.00	laboratory
26	Seminar: Amino acids fund and their uasge. AA catabolism. Specific properties of amino acids			Classes		1.00	laboratory
27	Blood and urine chemical composition. Creatinine and urea determination			Classes		1.00	laboratory
28	COLLOQUIUM: Lipid metabolism. Amino acid metabolism			Classes		1.00	laboratory
29	Hormonal regulation of metabolism. Xenobiotics metabolism			Classes		1.00	laboratory
Topic Layout (Part-Time)
No.	Topic			Type of Implementation		Number	Venue
1	Introduction to biochemistry. Biochemistry and pharmaceuticals. Proteins			Lectures		1.00	auditorium
3	Enzymes			Lectures		1.00	auditorium
4	Vitamins – water and fat soluble. Vitamins and coenzymes in medicine			Lectures		2.00	auditorium
6	Carbohydrate metabolism			Lectures		1.00	auditorium
7	Lipid metabolism			Lectures		1.00	auditorium
8	Amino acid metabolism			Lectures		1.00	auditorium
9	Hormonal regulation principles of metabolism. Metabolism of xenobiotics			Lectures		1.00	auditorium
12	Proof of enzyme specificity. Enzymatic reaction dependence on T ° and pH			Classes		1.00	laboratory
15	COLLOQUIUM: Proteins. Enzymes			Classes		1.00	laboratory
20	Seminar: Bioenergy. Antioxidant system. SDH demonstration. Hydroperoxidases			Classes		2.00	laboratory
22	Seminar: Glycolytic pathway of glucose metabolism. Oxidative decarboxylation of PVA. Gluconeogenesis. Seminar: Glycogen synthesis and degradation process. Non-energy pathways of glucose metabolism Lab work: Lactate proof in muscles			Classes		1.00	laboratory
24	Seminar: Triacylglycerol metabolism. Fatty acid metabolism. Ketones. Laboratory work: Demonstration of ketones			Classes		1.00	laboratory
26	Seminar: Amino acids fund and their uasge. AA catabolism. Specific properties of amino acids			Classes		1.00	laboratory
28	COLLOQUIUM: Lipid metabolism. Amino acid metabolism			Classes		1.00	laboratory
Assessment
Unaided Work:
Study independently the latest scientific literature and integrate it in educational material. In order to evaluate the quality of the study course as a whole, the student must fill out the study course evaluation questionnaire on the Student Portal.
Assessment Criteria:
1. Participation during practical lessons. 2. Participation in oral seminars. 3. Written intermediate colloquia. 4. Written exam with open questions. 5. Final grade - cumulative, where 70% - exam grade and 30% - colloquium grade.
Final Examination (Full-Time):		Exam (Written)
Final Examination (Part-Time):		Exam
Learning Outcomes
Knowledge:		Upon successful completion of the course the student will be able to: 1. Substantiate according biochemical processes in the normal course and anticipate possible changes to various deviations. 2. Analyse and substantiate medication effects on metabolic process, as well as predict the consequences on the body. 3. Analyse biochemically collected data during drug therapy, to adequately process them and to make consequential and reasoned conclusions.
Skills:		Upon completion of the study course the students will be able to: 1. Tell about the human body's molecules structure and importance. 2. Describe the enzyme activity. 3. Define the main principles of bioenergetics and metabolism, their regulation capabilities. 4. Analyse and evaluate carbohydrates, lipids and amino acid metabolic processes and its hormonal regulation. 5. Justify medication effects on metabolism in human body.
Competencies:		Will be able to predict and analyse the medication effects on metabolic processes, and to make consequential and reasoned conclusions by using data collected from drug therapy.
Bibliography
No.	Reference
Required Reading
1	Peter J. Kennelly, Kathleen M. Botham, Owen P. McGuinness, Victor W. Rodwell, P. Anthony Weil. Harper's Illustrated Biochemistry, 32nd Edition by Mc Graw Hill education), 2023: 820.
Additional Reading
1	R. A. Harvey, D. R. Ferrier. Lippincott's Illustrated Reviews: Biochemistry (Lippincott's Illustrated Reviews Series), 2021: 544.
2	Pub Med un citas datu bāzes.
3	L. W. Janson and M. E. Tischler „The Big Picture. Medical Biochemistry” Mc Graw Hill Medical, 2012
Other Information Sources
1	e-studijas