Medical Biochemistry

Study Course Description

Course Description Statuss:Approved

Course Description Version:2.00

Study Course Accepted:22.04.2024 10:28:14

Study Course Information
Course Code:		CFUBK_087		LQF level:		Level 7
Credit Points:		4.00		ECTS:		6.00
Branch of Science:		Clinical Medicine		Target Audience:		Dentistry
Study Course Supervisor
Course Supervisor:		Kalvis Brangulis
Study Course Implementer
Structural Unit:		Department of Human Physiology and Biochemistry
The Head of Structural Unit:
Contacts:		Riga, 16 Dzirciema Street, cfbkrsu[pnkts]lv, +371 67061550
Study Course Planning
Full-Time - Semester No.1
Lectures (count)		8	Lecture Length (academic hours)		2	Total Contact Hours of Lectures		16
Classes (count)		11	Class Length (academic hours)		3	Total Contact Hours of Classes		33
Total Contact Hours								49
Study course description
Preliminary Knowledge:
Chemistry and biology at secondary school level.
Objective:
To gain the knowledge about the structural and functional features of the macromolecules found in the living organisms. To acquire the knowledge about the chemical reactions, interactions and main metabolic processes that occur within the human organism.
Topic Layout (Full-Time)
No.	Topic			Type of Implementation		Number	Venue
1	Description of proteins. Enzymes: structure, influence of pH and T			Lectures		1.00	E-Studies platform
2	Enzymes: classification; mechanism of action; activity; specificity.			Lectures		1.00	E-Studies platform
3	Enzymes: activators and inhibitors. Digestion.			Lectures		1.00	E-Studies platform
4	Bioenergetics.			Lectures		1.00	E-Studies platform
5	Metabolism of Carbohydrates: glycolysis, anaerobic glycolysis; Cori cycle; oxidative decarboxylation.			Lectures		1.00	E-Studies platform
6	Krebs cycle; ETC; glycogenesis; glycogenolysis; gluconeogenesis; Pentose phosphate pathway.			Lectures		1.00	E-Studies platform
7	Metabolism of fats: oxidation and synthesis of fatty acids; ketogenesis.			Lectures		1.00	E-Studies platform
8	Metabolism of amino acids. Urea cycle.			Lectures		1.00	E-Studies platform
9	Influence of T and pH on enzymes activity.			Classes		1.00	laboratory
10	Specificity of enzymes.			Classes		1.00	laboratory
11	Activity of enzymes, activators and inhibitors of enzymes.			Classes		1.00	laboratory
12	Digestion of nutrients in human.			Classes		1.00	laboratory
13	Colloquium: proteins; enzymes; digestion.			Classes		1.00	laboratory
14	Bioenergetics.			Classes		1.00	laboratory
15	Metabolism of Carbohydrates.			Classes		1.00	laboratory
16	Metabolism of fats; ketogenesis.			Classes		1.00	laboratory
17	Metabolism of amino acids.			Classes		1.00	laboratory
18	Colloquium: metabolism of carbohydrates, fats and proteins.			Classes		1.00	laboratory
19	Seminar. Presentation.			Classes		1.00	laboratory
Assessment
Unaided Work:
Independently study the latest scientific literature and integrate it into the studying process. Independent preparation of the homework specified in the class protocols before the relevant seminar. Independently prepare/fill in class protocols. To make a presentation at the end of the course. Using the sources available in the e-studies and the mandatory literature specified in the e-studies to independently prepare for colloquiums and the exam. In order to evaluate the quality of the study course as a whole, the student must fill out the study course evaluation questionnaire on the Student Portal.
Assessment Criteria:
• attendance of the practical classes; • colloquiums in written form - during the study course there are 2 colloquia; • final exam in written form. • The final grade of the study course "Medical Biochemistry" consists of the cumulative assessment of the colloquia (50%) and the exam (50%).
Final Examination (Full-Time):		Exam (Written)
Final Examination (Part-Time):
Learning Outcomes
Knowledge:		After the study course the student will be able to: • describe the function and structure of the main macromolecules found in the human organism; • describe the structure and function of proteins, including general knowledge about the mechanism of enzymes; • explain the enzymatic digestion processes in the human organism; • describe the main metabolic processes in the human organism; • describe and recognize the biochemical reactions of the main metabolic pathways.
Skills:		After the study course the student will be able to use the acquired knowledge to: • describe and analyze the digestion process in the human organism; • analyze and evaluate the metabolism of carbohydrates, fats and proteins; • define the main metabolic processes and principles of bioenergetics, regulation; • describe the interconnections between different metabolic pathways.
Competencies:		The students will gain the necessary knowledge to understand what is necessary for biochemical processes to be fully operational and they will be able to analyze and discuss about the impact of various factors on the biochemical processes of the human organism.
Bibliography
No.	Reference
Required Reading
1	Victor Rodwell, P. Anthony Weil, David Bender, Kathleen M. Botham, Peter J. Kennelly. Harper's Illustrated Biochemistry, 30th Edition, 2018.
2	E-studijās ievietotie lekciju un nodarbību materiāli.
3	Nelson, D., and Cox, M. Lehninger principles of biochemistry, 8th Edition, 2021 (vai jaunāka versija)
4	Denise R. Ferrier. Lippincott Illustrated Reviews: Biochemistry, 6th Edition, 2017.
Additional Reading
1	Devlin's Textbook of Biochemistry with Clinical Correlations. Martin D. Snider. John Wiley & Sons, Incorporated, 2024
2	Marks' Basic Medical Biochemistry: A Clinical Approach. Michael A. Lieberman, Alisa Peet, Wolters Kluwer Health, 2022
Other Information Sources
1	PUBMED datubāze.