Pharmacogenetics

Study Course Description

Course Description Statuss:Approved

Course Description Version:8.00

Study Course Accepted:16.11.2022 10:41:48

Study Course Information
Course Code:		FKK_001		LQF level:		Level 7
Credit Points:		2.00		ECTS:		3.00
Branch of Science:		Basic Sciences of Medicine, including Pharmacy		Target Audience:		Pharmacy
Study Course Supervisor
Course Supervisor:		Renāte Ranka
Study Course Implementer
Structural Unit:		Department of Pharmaceutical Chemistry
The Head of Structural Unit:
Contacts:		Riga, 16 Dzirciema Street, Block A 5th floor, Room No 502, farmkkrsu[pnkts]lv, +371 67061544
Study Course Planning
Full-Time - Semester No.1
Lectures (count)		8	Lecture Length (academic hours)		2	Total Contact Hours of Lectures		16
Classes (count)		8	Class Length (academic hours)		2	Total Contact Hours of Classes		16
Total Contact Hours								32
Part-Time - Semester No.1
Lectures (count)		8	Lecture Length (academic hours)		2	Total Contact Hours of Lectures		16
Classes (count)		8	Class Length (academic hours)		2	Total Contact Hours of Classes		16
Total Contact Hours								32
Study course description
Preliminary Knowledge:
In biology, pharmacology and human genetics.
Objective:
To introduce students to the basic concepts of pharmacogenetics, research methods and the application of pharmacogenetics tests in modern health care.
Topic Layout (Full-Time)
No.	Topic			Type of Implementation		Number	Venue
1	Introduction into pharmacogenetics			Lectures		1.00	auditorium
2	Human genetics			Lectures		1.00	auditorium
3	Pharmacogenetics of drug metabolising enzymes 1			Lectures		1.00	auditorium
4	Pharmacogenetics of drug metabolising enzymes 2			Lectures		1.00	auditorium
5	Pharmacogenetics of drug metabolising enzymes 3			Lectures		1.00	auditorium
6	Cytochrome P450			Lectures		1.00	auditorium
7	Pharmacogenetics of drug targets			Lectures		1.00	auditorium
8	Research in pharmacogenetics			Lectures		1.00	auditorium
9	Introduction into pharmacogenetics			Classes		1.00	laboratory
10	Human genetics			Classes		1.00	laboratory
11	Pharmacogenetics of drug metabolizing enzymes 1			Classes		1.00	laboratory
12	Pharmacogenetics of drug metabolizing enzymes 2			Classes		1.00	laboratory
13	Pharmacogenetics of drug metabolizing enzymes 3			Classes		1.00	laboratory
14	Cytochrome P450			Classes		1.00	laboratory
15	Pharmacogenetics of drug targets			Classes		1.00	laboratory
16	Research in pharmacogenetics			Classes		1.00	laboratory
Topic Layout (Part-Time)
No.	Topic			Type of Implementation		Number	Venue
1	Introduction into pharmacogenetics			Lectures		1.00	auditorium
2	Human genetics			Lectures		1.00	auditorium
3	Pharmacogenetics of drug metabolising enzymes 1			Lectures		1.00	auditorium
4	Pharmacogenetics of drug metabolising enzymes 2			Lectures		1.00	auditorium
5	Pharmacogenetics of drug metabolising enzymes 3			Lectures		1.00	auditorium
6	Cytochrome P450			Lectures		1.00	auditorium
7	Pharmacogenetics of drug targets			Lectures		1.00	auditorium
8	Research in pharmacogenetics			Lectures		1.00	auditorium
9	Introduction into pharmacogenetics			Classes		1.00	auditorium
10	Human genetics			Classes		1.00	auditorium
11	Pharmacogenetics of drug metabolizing enzymes 1			Classes		1.00	auditorium
12	Pharmacogenetics of drug metabolizing enzymes 2			Classes		1.00	auditorium
13	Pharmacogenetics of drug metabolizing enzymes 3			Classes		1.00	auditorium
14	Cytochrome P450			Classes		1.00	auditorium
15	Pharmacogenetics of drug targets			Classes		1.00	auditorium
16	Research in pharmacogenetics			Classes		1.00	auditorium
Assessment
Unaided Work:
Within the course, the student prepares an independent work using scientific literature (books and scientific publications) in the form of a course work, which is presented in the seminar. Students must fill in the study course evaluation questionnaires.
Assessment Criteria:
The student understands the basic mechanisms of drug effects and side effects, which are related to human genetics. The student is familiar with the basic concepts and basic methods of the subject, knows examples of hereditary variations in the genes of various drug metabolism enzymes and their effect on drug metabolism, knows how to justify with concrete examples the effect of variations in the genes of drug receptors and transport proteins on the effect of drugs.
Final Examination (Full-Time):		Exam (Written)
Final Examination (Part-Time):		Exam (Written)
Learning Outcomes
Knowledge:		As a result of completing the study course, students acquire basic knowledge in the theory of pharmacogenetics, i.e. what is pharmacogenetics, what are the types and goals of pharmacogenetics research, how the characteristics of the human genome can affect the effect of medicinal products on the patient’s body and how medical personnel could predict these effects.
Skills:		As a result of completing the study course, students acquire skills in evaluating the influence of heredity factors in cases of variations in drug action and the ability to search for a solution to the situation. Will be able to explain social and clinical perspectives on interindividual variability in responses to drug substances.
Competencies:		As a result of completing the study course, students gain competence in issues related to the application of human genome research for the provision of personalised pharmacotherapy and the creation of new pharmacogenetic tests, as well as ethical aspects of pharmacogenetics.
Bibliography
No.	Reference
Required Reading
1	Clinical Applications of Pharmacogenetics. Edited by Despina Sanoudou. Publisher: InTech, 2012. DOI: 10.5772/1277 (Open Access book). (akceptējams izdevums)
2	Pharmacogenetics. Wendell W. Weber. Oxford Monographs on Medical Genetics, 2nd edition, 2008. (akceptējams izdevums)
Additional Reading
1	Pharmacogenomics: Social, Ethical, and Clinical Dimensions. Mark A. Rothstein.Wiley-Liss, 2003.
2	Biochemistry. D.Voet, J.Voet. Wiley, 2021.
3	Molecular Biology of the Cell. B.Alberts. Garland, 2015.
Other Information Sources
1	PubMed datu bāze.