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Medical Biochemistry

Study Course Description

Course Description Statuss:Approved
Course Description Version:1.00
Study Course Accepted:26.03.2024 16:36:15
Study Course Information
Course Code:CFUBK_085LQF level:Level 7
Credit Points:4.67ECTS:7.00
Branch of Science:Clinical Medicine; Medical BiochemistryTarget Audience:Pharmacy
Study Course Supervisor
Course Supervisor:Ināra Nokalna
Study Course Implementer
Structural Unit:Department of Human Physiology and Biochemistry
The Head of Structural Unit:
Contacts:Riga, 16 Dzirciema Street, cfbkatrsu[pnkts]lv, +371 67061550
Study Course Planning
Full-Time - Semester No.1
Lectures (count)11Lecture Length (academic hours)2Total Contact Hours of Lectures22
Classes (count)12Class Length (academic hours)2Total Contact Hours of Classes24
Total Contact Hours46
Full-Time - Semester No.2
Lectures (count)7Lecture Length (academic hours)2Total Contact Hours of Lectures14
Classes (count)9Class Length (academic hours)2Total Contact Hours of Classes18
Total Contact Hours32
Part-Time - Semester No.1
Lectures (count)7Lecture Length (academic hours)2Total Contact Hours of Lectures14
Classes (count)6Class Length (academic hours)2Total Contact Hours of Classes12
Total Contact Hours26
Study course description
Preliminary Knowledge:
General and organic chemistry, biology in high school and FF II course program level.
Objective:
1. To promote the acquisition of knowledge about the human body's chemical structure. 2. Learn the metabolism, the opportunities of regulation and changes in different situations. 3. Learn the possible routes of drugs, their inactivation processes.
Topic Layout (Full-Time)
No.TopicType of ImplementationNumberVenue
1Introduction to biochemistry. Biochemistry and pharmaceuticals. ProteinsLectures1.00auditorium
2Simple proteins. Compound proteins. Chromoproteins. EnzymesLectures2.00auditorium
3EnzymesLectures2.00auditorium
4Vitamins – water and fat soluble. Vitamins and coenzymes in medicineLectures1.00auditorium
5Metabolism. Central catabolic pathways. Krebs cycle ATP formation pathways. Oxidants and antioxidative systemLectures3.00auditorium
6Carbohydrate metabolismLectures3.00auditorium
7Lipid metabolismLectures2.00auditorium
8Amino acid metabolismLectures3.00auditorium
9Hormonal regulation principles of metabolism. Metabolism of xenobioticsLectures1.00auditorium
10Most important functional groups in biochemistry and their propertiesClasses1.00laboratory
11Proof reactions of amino acids. Proof reactions of amino acids. Protein quantitative determination techniques. Protein quantitative determination techniques. Chromoproteins. Hemoglobin forms of spectroscopyClasses1.00laboratory
12Proof of enzyme specificity. Enzymatic reaction dependence on T ° and pHClasses1.00laboratory
13Enzyme activity detection methodsClasses1.00laboratory
14Enzyme activators and inhibitorsClasses1.00laboratory
15COLLOQUIUM: Proteins. EnzymesClasses1.00laboratory
16Proof of water-soluble vitaminsClasses1.00laboratory
17Nutrient digestive processClasses1.00laboratory
18Protein, fat and carbohydrate digestionClasses1.00laboratory
19COLLOQUIUM: VitaminsClasses1.00laboratory
20Seminar: Bioenergy. Antioxidant system. SDH demonstration. HydroperoxidasesClasses1.00laboratory
21COLLOQUIUM: BioenergeticsClasses1.00laboratory
22Seminar: Glycolytic pathway of glucose metabolism. Oxidative decarboxylation of PVA. Gluconeogenesis. Seminar: Glycogen synthesis and degradation process. Non-energy pathways of glucose metabolism Lab work: Lactate proof in musclesClasses2.00laboratory
23Colloquium: Glucose metabolismClasses1.00laboratory
24Seminar: Triacylglycerol metabolism. Fatty acid metabolism. Ketones. Laboratory work: Demonstration of ketonesClasses1.00laboratory
25Seminar: Cholesterol. Synthesis of phospholipids and fats. Lab. work: Determination of cholesterol in the analysisClasses1.00laboratory
26Seminar: Amino acids fund and their uasge. AA catabolism. Specific properties of amino acidsClasses1.00laboratory
27Blood and urine chemical composition. Creatinine and urea determinationClasses1.00laboratory
28COLLOQUIUM: Lipid metabolism. Amino acid metabolismClasses1.00laboratory
29Hormonal regulation of metabolism. Xenobiotics metabolismClasses1.00laboratory
Topic Layout (Part-Time)
No.TopicType of ImplementationNumberVenue
1Introduction to biochemistry. Biochemistry and pharmaceuticals. ProteinsLectures1.00auditorium
3EnzymesLectures1.00auditorium
4Vitamins – water and fat soluble. Vitamins and coenzymes in medicineLectures1.00auditorium
6Carbohydrate metabolismLectures1.00auditorium
7Lipid metabolismLectures1.00auditorium
8Amino acid metabolismLectures1.00auditorium
9Hormonal regulation principles of metabolism. Metabolism of xenobioticsLectures1.00auditorium
12Proof of enzyme specificity. Enzymatic reaction dependence on T ° and pHClasses1.00laboratory
15COLLOQUIUM: Proteins. EnzymesClasses1.00laboratory
22Seminar: Glycolytic pathway of glucose metabolism. Oxidative decarboxylation of PVA. Gluconeogenesis. Seminar: Glycogen synthesis and degradation process. Non-energy pathways of glucose metabolism Lab work: Lactate proof in musclesClasses1.00laboratory
24Seminar: Triacylglycerol metabolism. Fatty acid metabolism. Ketones. Laboratory work: Demonstration of ketonesClasses1.00laboratory
26Seminar: Amino acids fund and their uasge. AA catabolism. Specific properties of amino acidsClasses1.00laboratory
28COLLOQUIUM: Lipid metabolism. Amino acid metabolismClasses1.00laboratory
Assessment
Unaided Work:
Study independently the latest scientific literature and integrate it in educational material. In order to evaluate the quality of the study course as a whole, the student must fill out the study course evaluation questionnaire on the Student Portal.
Assessment Criteria:
1. Participation in practical classes. 2. Participation in the oral workshops. 3. Written colloquiums. 4. Written exam. 5. Final grade - cumulative, where 70% - exam grade and 30% - colloquium grade.
Final Examination (Full-Time):Exam (Written)
Final Examination (Part-Time):Exam
Learning Outcomes
Knowledge:Upon successful completion of the course the student will be able to: 1. Substantiate according biochemical processes in the normal course and anticipate possible changes to various deviations. 2. Analyse and substantiate medication effects on metabolic process, as well as predict the consequences on the body. 3. Analyse biochemically collected data during drug therapy, to adequately process them and to make consequential and reasoned conclusions.
Skills:Upon completion of the study course the students will be able to: 1. Tell about the human body's molecules structure and importance. 2. Describe the enzyme activity. 3. Define the main principles of bioenergetics and metabolism, their regulation capabilities. 4. Analyse and evaluate carbohydrates, lipids and amino acid metabolic processes and its hormonal regulation. 5. Justify medication effects on metabolism in human body.
Competencies:Will be able to predict and analyse the medication effects on metabolic processes, and to make consequential and reasoned conclusions by using data collected from drug therapy.
Bibliography
No.Reference
Required Reading
1V. W. Rodwell, D. K. Granner, D.A. Bender, P. J. Kennelly. Harper's Illustrated Biochemistry (30th edition by Mc Graw Hill education), 2018: 820.
Additional Reading
1R. A. Harvey, D. R. Ferrier. Lippincott's Illustrated Reviews: Biochemistry (Lippincott's Illustrated Reviews Series), 2021: 544.
2Pub Med un citas datu bāzes.
3L. W. Janson and M. E. Tischler „The Big Picture. Medical Biochemistry” Mc Graw Hill Medical, 2012
Other Information Sources
1e-studijas