Medical Chemistry

Study Course Description

Course Description Statuss:Approved

Course Description Version:9.00

Study Course Accepted:24.03.2022 09:38:05

Study Course Information
Course Code:		FKK_006		LQF level:		Level 7
Credit Points:		2.00		ECTS:		3.00
Branch of Science:		Chemistry		Target Audience:		Pharmacy
Study Course Supervisor
Course Supervisor:		Reinis Vilšķērsts
Study Course Implementer
Structural Unit:		Department of Pharmaceutical Chemistry
The Head of Structural Unit:
Contacts:		Riga, 16 Dzirciema Street, Block A, 5th floor, Room No 502, farmkkrsu[pnkts]lv, +371 67061544
Study Course Planning
Full-Time - Semester No.1
Lectures (count)		4	Lecture Length (academic hours)		2	Total Contact Hours of Lectures		8
Classes (count)		8	Class Length (academic hours)		3	Total Contact Hours of Classes		24
Total Contact Hours								32
Part-Time - Semester No.1
Lectures (count)		4	Lecture Length (academic hours)		4	Total Contact Hours of Lectures		16
Classes (count)		4	Class Length (academic hours)		4	Total Contact Hours of Classes		16
Total Contact Hours								32
Study course description
Preliminary Knowledge:
Knowledge of organic chemistry, physiology, biochemistry.
Objective:
To introduce students to medicinal chemistry and to enable students to the opportunity to learn about medicinal substance existing and change in the body from the administration until elimination.
Topic Layout (Full-Time)
No.	Topic			Type of Implementation		Number	Venue
1	Introduction, receptors and methods in medicinal chemistry			Lectures		1.00	auditorium
2	Enzyme inhibitors. Introduction in Pharmacokinetics			Lectures		1.00	auditorium
3	G protein-coupled receptors			Classes		1.00	auditorium
4	Drug metabolism			Lectures		1.00	auditorium
5	Ion channels			Classes		1.00	auditorium
6	Cardiovascular drugs			Lectures		1.00	auditorium
7	Prodrugs			Classes		1.00	auditorium
8	Biotransformation reactions of drug substances			Classes		1.00	auditorium
9	Drug dose calculations by using the pharmacokinetic parameters			Classes		1.00	auditorium
10	Multitarget drugs. Drug metabolism. Team work/seminar			Classes		1.00	auditorium
11	Analysis of scientific publication of medicinal chemistry			Classes		1.00	auditorium
12	Test			Classes		1.00	auditorium
Topic Layout (Part-Time)
No.	Topic			Type of Implementation		Number	Venue
1	Introduction, receptors and methods in medicinal chemistry			Lectures		1.00	auditorium
2	Enzyme inhibitors. Introduction in Pharmacokinetics			Lectures		1.00	auditorium
3	G protein-coupled receptors			Classes		0.50	auditorium
4	Drug metabolism			Lectures		1.00	auditorium
5	Ion channels			Classes		0.50	auditorium
6	Cardiovascular drugs			Lectures		1.00	auditorium
7	Prodrugs			Classes		0.50	auditorium
8	Biotransformation reactions of drug substances			Classes		0.50	auditorium
9	Drug dose calculations by using the pharmacokinetic parameters			Classes		0.50	auditorium
10	Multitarget drugs. Drug metabolism. Team work/seminar			Classes		0.50	auditorium
11	Analysis of scientific publication of medicinal chemistry			Classes		0.50	auditorium
12	Test			Classes		0.50	auditorium
Assessment
Unaided Work:
Individual and group situation tasks during seminars and colloquia; preparation of presentation, analysis of scientific publications in medicinal chemistry.
Assessment Criteria:
Analysis of the article in medicinal chemistry, ability to create new hypothetical compounds with desirable pharmacological activity, presentation of results.
Final Examination (Full-Time):		Exam (Written)
Final Examination (Part-Time):		Exam (Written)
Learning Outcomes
Knowledge:		Student will be able to: • Describe and explain process of mutual interactions of drug substances with various types of receptors; • Describe metabolic changes of drugs; • Explain drug interactions; • Explain prodrugs; • Identify and characterize frequently used groups of cardiovascular drugs.
Skills:		Student will be able to: • Identify mechanisms of pharmacological action of the most important groups of medications (enzyme inhibitors, inducers, calcium channel blockers and other); • Objectively evaluate the possible origin of the substance interaction in case of co-administration; • Analyse the articles in medicinal chemistry.
Competencies:		Students will be able to assess the physico-chemical principles of drug substances, the possibility of interaction, origin of interaction and structure – activity interaction.
Bibliography
No.	Reference
Required Reading
1	Patrick, Graham L. An introduction to medicinal chemistry / Graham L. Patrick. 6th edition. NY: Oxford University Press, 2017. 1703 xxxi, 877 lpp.
2	Strohfeldt-Venables, Katja Essentials of inorganic chemistry: for students of pharmacy, pharmaceutical sciences and medicinal chemistry / Katja A. Strohfeldt, School of Pharmacy, University of Reading, UK. Chichester, West Sussex: Wiley, 2015. xiv,
3	Ahluwalia, V. K. Medicinal chemistry / V. K. Ahluwalia, Madhu Chopra. New Delhi : Ane Books India, 2008. xxii, 340 lpp. (akceptējams izdevums)
4	The practice of medicinal chemistry / edited by Camille Georges Wermuth. 3rd edition. Amsterdam [etc.]: Elsevier/Academic Press, 2015. xxxix, 942 lpp.
Additional Reading
1	Essentials of pharmaceutical chemistry / edited by Donald Cairns. 4th edition. London: Pharmaceutical Press, c2012. viii, 308 lpp.
2	Medicinal Chemistry Self Assessment. By: Zavod, Robin M.; Harrold, Marc W. Bethesda, MD: ASHP. 2015.
3	New Developments in Medicinal Chemistry. By: Gil, Irene C.; Ortega, Marta P. New York: Nova Science Publishers, Inc. 2009. eBook., ProQuest Ebook Central datubāzē
Other Information Sources
1	Zinātniskās literatūras datubāzes: Pubmed; ScienceDirect (http://www.sciencedirect.com/) etc.