Organic Chemistry

Study Course Description

Course Description Statuss:Approved

Course Description Version:7.00

Study Course Accepted:20.03.2024 15:40:32

Study Course Information
Course Code:		FKK_031		LQF level:		Level 7
Credit Points:		9.00		ECTS:		13.50
Branch of Science:		Chemistry		Target Audience:		Pharmacy
Study Course Supervisor
Course Supervisor:		Māra Plotniece
Study Course Implementer
Structural Unit:		Department of Pharmaceutical Chemistry
The Head of Structural Unit:
Contacts:		16 Dzirciema Street, Room No A-502, farmkkrsu[pnkts]lv
Study Course Planning
Full-Time - Semester No.1
Lectures (count)		10	Lecture Length (academic hours)		2	Total Contact Hours of Lectures		20
Classes (count)		15	Class Length (academic hours)		3	Total Contact Hours of Classes		45
Total Contact Hours								65
Full-Time - Semester No.2
Lectures (count)		6	Lecture Length (academic hours)		2	Total Contact Hours of Lectures		12
Classes (count)		14	Class Length (academic hours)		5	Total Contact Hours of Classes		70
Total Contact Hours								82
Part-Time - Semester No.1
Lectures (count)		14	Lecture Length (academic hours)		4	Total Contact Hours of Lectures		56
Classes (count)		14	Class Length (academic hours)		4	Total Contact Hours of Classes		56
Total Contact Hours								112
Study course description
Preliminary Knowledge:
Knowledge of organic chemistry within the programme of secondary school, inorganic chemistry, laboratory techniques.
Objective:
Learn basic course of organic chemistry for further understanding of biochemistry, medical chemistry and pharmaceutical science.
Topic Layout (Full-Time)
No.	Topic			Type of Implementation		Number	Venue
1	Basic of organic chemistry			Lectures		1.00	auditorium
2	Seminar: nomenclature of organic compounds. Test: nomenclature of organic compounds.			Classes		1.00	laboratory
3	Seminar: acidity and basicity of organic compounds, stereochemistry. Test: acidity and basicity of organic compounds, stereochemistry.			Classes		1.00	laboratory
4	Hydrocarbons.			Lectures		2.00	auditorium
5	Colloquium: Basic of organic chemistry			Classes		1.00	laboratory
6	Practical work: chemical properties and identification reactions of hydrocarbons. Seminar: chemical properties and identification reactions of hydrocarbons. Test: chemical properties and identification reactions of hydrocarbons.			Classes		2.00	laboratory
7	Introduction to spectroscopy (IR un 1H NMR spectroscopy for identification of organic compounds)			Lectures		1.00	auditorium
8	Organic halides, alcohols, phenols, ethers, sulfur containing compounds.			Lectures		1.00	auditorium
9	Colloquium: hydrocarbons			Classes		1.00	laboratory
10	Practical work and seminar: chemical properties and identification reactions of organic halides, alcohols, phenols, ethers, sulfur containing compounds			Classes		1.00	laboratory
11	Colloquium: organic halides, alcohols, phenols, ethers, sulfur containing compounds.			Classes		1.00	laboratory
12	Carbonylcompounds: Aldehydes and ketones			Lectures		1.00	auditorium
13	Practical work: chemical properties and identification reactions of aldehydes and ketones			Classes		1.00	laboratory
14	Amines, diazonium ions, azocompounds and other nitrogen containing compounds			Lectures		2.00	auditorium
15	Colloquium: aldehydes and ketones (carbonylcompounds).			Classes		1.00	laboratory
16	Practical work: chemical properties and identification reactions of amines, diazonium ions and azocompounds.			Classes		1.00	laboratory
17	Seminar: chemical properties and identification reactions of amines, diazonium ions and azocompounds.			Classes		1.00	laboratory
18	Carboxylic acids			Lectures		1.00	auditorium
19	Carboxylic acid derivatives, different functional group containing carboxylic acids, derivatives of carbonic acid, sulfonic acids.			Lectures		1.00	auditorium
20	Colloquium: amines, diazonium ions and azocompounds			Classes		1.00	laboratory
22	Practical work: chemical properties and identification reactions of carboxylic acids and their derivatives. Seminar: chemical properties and identification reactions of carboxylic acids and their derivatives.			Classes		1.00	laboratory
23	Colloquium: carboxylic acids and their derivatives. FINNAL TEST			Classes		1.00	laboratory
24	Heterocycles			Lectures		2.00	auditorium
25	Practical work: Purification of organic com-pounds: crystallization, fractional distillation, sublimation, extraction. Colloquium: Basic of organic chemistry.			Classes		2.00	laboratory
26	Seminar: Heterocycles: clasification and no-menclature, heterocycles with one heteroatom, heterocycles with two heteroatoms, purine, pteridine, alkaloids.			Classes		1.00	laboratory
27	Practical work: Synthesis of organic compounds (individual work)			Classes		3.00	laboratory
28	Test: Heterocycles			Classes		0.50	laboratory
29	Carbohydrates			Lectures		2.00	auditorium
30	Colloquium: Heterocycles. Seminar: Carbohydrates.			Classes		2.00	laboratory
31	Test: Carbohydrates			Classes		0.50	laboratory
32	Colloquium: Carbohydrates.			Classes		1.00	laboratory
33	Aminoacids, peptides, nucleic acids			Lectures		1.00	auditorium
34	Seminar: Aminoacids, peptides, nucleic acids.			Classes		1.00	laboratory
35	Colloquium: Aminoacids, peptides, nucleic acids.			Classes		0.50	laboratory
36	Seminar: Lipids. Practical work: Identification of organic compound using chemical and spectroscopic methods.			Classes		2.00	laboratory
37	Lipids. Cholesterol.			Lectures		1.00	auditorium
38	Colloquium: Lipids, cholesterol.			Classes		0.50	laboratory
Topic Layout (Part-Time)
No.	Topic			Type of Implementation		Number	Venue
1	Basic of organic chemistry			Lectures		1.00	auditorium
2	Seminar: nomenclature of organic compounds. Test: nomenclature of organic compounds.			Classes		0.50	laboratory
3	Seminar: acidity and basicity of organic compounds, stereochemistry. Test: acidity and basicity of organic compounds, stereochemistry.			Classes		0.50	laboratory
4	Hydrocarbons.			Lectures		2.00	auditorium
6	Practical work: chemical properties and identification reactions of hydrocarbons. Seminar: chemical properties and identification reactions of hydrocarbons. Test: chemical properties and identification reactions of hydrocarbons.			Classes		1.00	laboratory
8	Organic halides, alcohols, phenols, ethers, sulfur containing compounds.			Lectures		1.00	auditorium
9	Colloquium: hydrocarbons			Classes		1.00	laboratory
10	Practical work and seminar: chemical properties and identification reactions of organic halides, alcohols, phenols, ethers, sulfur containing compounds			Classes		1.00	laboratory
11	Colloquium: organic halides, alcohols, phenols, ethers, sulfur containing compounds.			Classes		1.00	laboratory
12	Carbonylcompounds: Aldehydes and ketones			Lectures		1.00	auditorium
13	Practical work: chemical properties and identification reactions of aldehydes and ketones			Classes		0.50	laboratory
14	Amines, diazonium ions, azocompounds and other nitrogen containing compounds			Lectures		1.50	auditorium
15	Colloquium: aldehydes and ketones (carbonylcompounds).			Classes		1.00	laboratory
16	Practical work: chemical properties and identification reactions of amines, diazonium ions and azocompounds.			Classes		1.00	laboratory
17	Seminar: chemical properties and identification reactions of amines, diazonium ions and azocompounds.			Classes		1.00	laboratory
18	Carboxylic acids			Lectures		1.00	auditorium
19	Carboxylic acid derivatives, different functional group containing carboxylic acids, derivatives of carbonic acid, sulfonic acids.			Lectures		1.00	auditorium
21	Dicarboxylic acids			Lectures		0.50	auditorium
22	Practical work: chemical properties and identification reactions of carboxylic acids and their derivatives. Seminar: chemical properties and identification reactions of carboxylic acids and their derivatives.			Classes		0.50	laboratory
23	Colloquium: carboxylic acids and their derivatives. FINNAL TEST			Classes		1.00	laboratory
24	Heterocycles			Lectures		1.50	auditorium
26	Seminar: Heterocycles: clasification and no-menclature, heterocycles with one heteroatom, heterocycles with two heteroatoms, purine, pteridine, alkaloids.			Classes		1.00	laboratory
29	Carbohydrates			Lectures		1.50	auditorium
30	Colloquium: Heterocycles. Seminar: Carbohydrates.			Classes		0.50	laboratory
32	Colloquium: Carbohydrates.			Classes		1.00	laboratory
33	Aminoacids, peptides, nucleic acids			Lectures		1.00	auditorium
35	Colloquium: Aminoacids, peptides, nucleic acids.			Classes		1.00	laboratory
37	Lipids. Cholesterol.			Lectures		1.00	auditorium
38	Colloquium: Lipids, cholesterol.			Classes		0.50	laboratory
Assessment
Unaided Work:
Individual laboratory experiments, problem solving, preparation, presentation and defence of literature research on specific drug substance. Individual work with home tasks, laboratory work protocol processing, studying of lecture materials. It is recommended to fill in the study course survey, evaluating the existing course content and creating proposals for updating the course.
Assessment Criteria:
1. Knowledge evaluation during practical sessions – discussions, seminars, colloquia, evaluation of results of experimental work; 2. Application of theoretical knowledge in practical tasks; 3. Assessment of student's attitude (activity in seminars, ability to improve knowledge, ability to work in a team explaining to others, attendance); 4. Analysis of unknown substance at the end of semester 3, performing various reactions and drawing conclusions on the presence of functional groups in the molecule; 5. Semester test at the end of the 2nd semester; 6. Written examination at the end of the 3rd semester.
Final Examination (Full-Time):		Exam (Written)
Final Examination (Part-Time):		Exam (Written)
Learning Outcomes
Knowledge:		On successful course completion students will: • identify functional groups of organic compounds and explain their properties and possibilities of mutual conversions; • interpret relations of special structures of molecules with their properties; • identify structures of heterocyclic compounds and their properties; • interpret reactions of organic compounds on the bases of the main principles of reaction mechanisms.
Skills:		On successful course completion students will: • recognize functional groups in drug molecules, name them, know the chemical properties and identification reactions of the group; • select and apply correct methods for isolation and purification of organic compounds; • evaluate chemical structures of drug substances in connection with their pharmacological actions.
Competencies:		On successful course completion students will choose and interpret chemical and physical methods of identification and functional analysis of organic compounds.
Bibliography
No.	Reference
Required Reading
1	P.M. Dewick. Essentiasl of Organic Chemistry. John Wiley & Son’s, England, 2006. (akceptējams izdevums)
2	K.P.C. Vollhardt, N.E. Shore. Organic Chemistry: Structure and Function. 7th ed. New York, N.Y. : W.H. Freeman and Company, 2014.
3	Органическая химия. Книга 1. Подред. Н.А. Тюкавкиной. М. 2003. (akceptējams izdevums)
4	Органическая химия. Книга 2.Спец.курсс. Подред. Н.А. Тюкавкиной. М. 2009. (akceptējams izdevums)
5	T.W. Graham Solomons. Solomons' Organic Chemistry. University of South Florida, 2017.
Additional Reading
1	R. Valters. Organiskā ķīmija (speckurss). RTU Rīga, 2009
2	R. Valters. Heterociklisko savienojumu ķīmija. RTU Rīga, 1995.
3	R. Valters. Kodolu magnētiskās rezonanses spektroskopija. RTU Rīga, 2008.
4	V. Alagarsamy. Pharmaceutical Organic Chemistry. BSP BOOKS, 2020, e-book.
5	Rawn, J. David; Ouellette, Robert J. Organic Chemistry: structure, mechanism, and synthesis. 1st ed. San Diego, CA : Elsevier. 2014. eBook.
6	Тюкавкина Н.А. Бауков Ю.И. Биоорганическая химия. М. 1991.
7	Armarego, W. L. F.; Chai, Christina Li Lin. Purification of laboratory chemicals. 6th ed. Oxford : Butterworth-Heinemann. 2012. eBook.
8	Ārvalstu studentiem/For international students
9	V. Alagarsamy. Pharmaceutical Organic Chemistry. BSP BOOKS, 2020, e-book.
10	Armarego, W. L. F.; Chai, Christina Li Lin. Purification of laboratory chemicals. 6th ed. Oxford : Butterworth-Heinemann. 2012. eBook.