Pharmaceutical Chemistry

Study Course Description

Course Description Statuss:Approved

Course Description Version:2.00

Study Course Accepted:21.06.2024 08:30:26

Study Course Information
Course Code:		FKK_048		LQF level:		Level 7
Credit Points:		8.67		ECTS:		13.00
Branch of Science:		Basic Sciences of Medicine, including Pharmacy		Target Audience:		Pharmacy
Study Course Supervisor
Course Supervisor:		Dace Bandere
Study Course Implementer
Structural Unit:		Department of Pharmaceutical Chemistry
The Head of Structural Unit:
Contacts:		Riga, 16 Dzirciema Street, block A 5th Floor, Room No 502, farmkkrsu[pnkts]lv, +371 67061544
Study Course Planning
Full-Time - Semester No.1
Lectures (count)		10	Lecture Length (academic hours)		2	Total Contact Hours of Lectures		20
Classes (count)		14	Class Length (academic hours)		4	Total Contact Hours of Classes		56
Total Contact Hours								76
Full-Time - Semester No.2
Lectures (count)		0	Lecture Length (academic hours)		0	Total Contact Hours of Lectures		0
Classes (count)		16	Class Length (academic hours)		4	Total Contact Hours of Classes		64
Total Contact Hours								64
Study course description
Preliminary Knowledge:
Basic knowledge in inorganic, organic and analytical chemistry, physical pharmacy.
Objective:
Course is aimed to acquire the theoretical knowledge and practical skills that can be used in drug quality control. • Promote knowledge of the main classes of medicinal products and their chemical properties; • Promote understanding of drug structure, synthesis, quality control and specifics of use; • Master the tactics of naming medicines and methods of testing the goodness of medicines; • Carry out the analysis of drug substances containing different dosage forms on the basis of physical and chemical properties, chemical structure and stability.
Topic Layout (Full-Time)
No.	Topic			Type of Implementation		Number	Venue
1	Methods of European Pharmacopeia. Quality control of water and injection water. Purified and injection water acquisition and quality testing.			Lectures		1.00	auditorium
2	Inorganic drugs. Chemical structure, methods of analysis, the use of medicine.			Lectures		1.00	auditorium
3	Analysis of functional groups and nomenclature of drugs			Lectures		2.00	auditorium
4	Anaesthesic drugs. Chemical structure, methods of analysis, medical use.			Lectures		1.00	auditorium
5	Non-steroidal anti inflamatory drugs and analgetics. Chemical structure, methods of analysis, medical use.			Lectures		1.00	auditorium
6	Synthetic antimicrobial drugs. Chemical structure, methods of analysis, medical use.TB drugs. Antiviral and Antiparasitic drugs. Chemical structure, methods of analysis, medical use.			Lectures		1.00	auditorium
7	Water and fat-soluble vitamins: chemical structure, physico-chemical properties, methods of analysis, the use of medicine.			Lectures		2.00	auditorium
8	Antibiotics and steroidal hormones: chemical structure, physico-chemical properties, methods of analysis, the use of medicine.			Lectures		1.00	auditorium
9	Preparation of standard solutions. Determination of drug turbidity, color and impurities.			Classes		1.00	laboratory
10	Quality control of purified water.			Classes		0.50	laboratory
11	Quality control of Boric acid sol.			Classes		0.50	laboratory
12	Analysis of inorganic substances.			Classes		1.00	laboratory
13	Quality control of NaF and CaCl2.			Classes		1.00	laboratory
14	Quality control of Sodium thiosulfate sol.			Classes		1.00	laboratory
15	Colloquium – Methods of European Pharmacopeia. Quality control of water and injection water. Inorganic drugs.			Classes		0.50	laboratory
16	Analysis of functional groups.			Classes		1.00	laboratory
17	Quality control of Rezorcin.			Classes		1.00	laboratory
18	Quality control of Na citrate sol.			Classes		1.00	laboratory
19	Colloquium – Analysis of functional groups. Drug naming.			Classes		0.50	laboratory
20	Quality control of Anesthesia drugs and NSAIDs			Classes		1.00	laboratory
21	Quality control of Procaine sol. and Paracetamol.			Classes		1.00	laboratory
22	NSAIDs melting point detection.			Classes		1.00	laboratory
23	Colloquium – Anesthesia drugs and NSAIDs.			Classes		1.00	laboratory
24	Pharmaceutical calculations			Classes		1.00	laboratory
25	Quality control of Sulfonamides and Isoniazid.			Classes		1.00	laboratory
26	Spectroscopic and jodometric analysis of Nitrofuran sol.			Classes		1.00	laboratory
27	Colloquium – CNS drugs. Drugs Used in Respiratory and Gastrointestinal Disorders. Antibacterial drugs.			Classes		1.00	laboratory
28	Control analysis – identification of an unknown medicinal substance.			Classes		2.00	laboratory
29	Presentation, analysis, discussion of the individual project.			Classes		1.00	laboratory
30	Introduction of express analysis. Express analysis of mixture, quantitative calculations (seminar).			Classes		1.00	laboratory
31	Vitamins identification reactions. Unknown vitamin preparation determination.			Classes		1.00	laboratory
32	Colloquium: Vitamins: synthesis, analysis and the use of medicine. Situation tasks of express analysis.			Classes		1.00	laboratory
33	Analysis of oral solutions.			Classes		1.00	laboratory
34	Quantitative analysis of multi dose powders.			Classes		1.00	laboratory
35	Antibiotics: chemical structure, physico-chemical properties, methods of analysis, the use of medicine.			Classes		1.00	laboratory
36	Hormones: chemical structure, physico-chemical properties, methods of analysis, the use of medicine.			Classes		1.00	laboratory
37	Final test - Pharmaceutical calculations.			Classes		1.00	laboratory
38	HPLC in drug analysis			Classes		1.00	laboratory
39	Gas chromatography for the analysis of ethanol solutions.			Classes		1.00	laboratory
Assessment
Unaided Work:
During the course students are asked to work with pharmaceutical literature sources to find drug quality control methods. Students are also independently preparing for each lab work finding answers for a set of specific questions in connection with the experimental tasks that helps to understand the experimental work during the labs. A research work – literature review. Study course evaluation questionnaire.
Assessment Criteria:
Active participation in practical classes and accuracy of laboratory work analyses; objective tests, report - literature review, presentations. Assessment – Colloquium grades 80%, report – 20%. Summative exam. Exam 50% of the grade.
Final Examination (Full-Time):		Exam (Written)
Final Examination (Part-Time):
Learning Outcomes
Knowledge:		On successful course completion: • Students should know structures and names of drug substances, methods of drug quality analysis, • be able to identify a compound by reactions of key functional groups, • be able to test the quality of different drug substances, • be able to identify the structural elements of vitamins, hormones and antibiotic drug substances and name a specific drug-containing preparation; • be able to explain the physico-chemical properties of vitamins, hormones and antibiotic drug substances, • be able to compare and select methods for drug substance synthesis, qualitative and quantitative analysis depending on the particular drug substance preparation.
Skills:		On successful course completion students will be able to: • choose and apply chemical and instrumental methods of analysis of drugs, • systematize scientific information of the different groups of medications, their characteristics, properties and use in medicine.
Competencies:		On successful course completion students will be able to evaluate and present the information of drug quality control; Students will be able to independently test the quality of the drug substance based on its physical and chemical properties.
Bibliography
No.	Reference
Required Reading
1	European Pharmacopoeia. 10th edition. Strasbourg: Council of Europe, 2019-2021. RSU: Informācijas centrs
2	RSU abonētās zinātniskās datubāzes.
3	Ārvalstu studentiem/For international students
4	European Pharmacopoeia. 10th edition. Strasbourg: Council of Europe, 2019-2021. RSU: Informācijas centrs
Additional Reading
1	Patrick, Graham L. An introduction to medicinal chemistry. 2017.
2	Hansen, S., Pedersen-Bjergaard, S., Rasmussen, K. Introduction to Pharmaceutical Chemical Analysis. Wiley-Blackwell, 2011.
3	Hill R.G. (ed) Drug Discovery and Development, Hill R.G, 2022.
4	Беликов, В. Г. Фармацевтическая химия. В 2 ч. Ч. 1: Общая фармацевтическая химия. Ч. 2: Специальная фармацевтическая химия: Учебник для мед. вузов. М.: Медпресс-информ, 1985. 624 с.
5	Shargel, L, Wu-Pong, S and Yu, A. Shargel and Yu's applied biopharmaceutics and pharmacokinetics: Bioavailability and bioequivalence. 8th ed. McGraw Hill: New York, USA, 2022.
6	Block, I .H., Beale, I. M. Wilson and Gisvold Textbook of Organic Medicinal and Pharmaceutical Chemistry. Delgado JN, Remers WA, (Eds.)., 12th ed. 2011.
7	Applications of Pharmacokinetic Principles in Drug Development. Editor Krishna R. Kluwer. Academic / Plenum Publishers, 2004. pp. 556.
8	Hillisch, A., Hilgenfeld, R. (eds). Modern Methods of Drug Discovery. Basel – Boston – Berlin, 2003.
9	Wermuth, C.G. (ed). The Practice of Medicinal Chemistry, Amsterdam, 2015.
10	Cairns, D. Essentials of Pharmaceutical Chemistry. Pharmaceutical Press, London 2012.
11	Ābola, D., Štokmane, A., Vīgestāne, R. Zāļu analīze aptiekā. Rīga: Zvaigzne, 1991.
12	Ārvalstu studentiem/For international students
13	Patrick, Graham L. An introduction to medicinal chemistry. 2017.
14	Hansen, S., Pedersen-Bjergaard, S., Rasmussen, K. Introduction to Pharmaceutical Chemical Analysis. Wiley-Blackwell, 2011.
15	Hill R.G. (ed) Drug Discovery and Development, Hill R.G, 2022.
16	Shargel, L, Wu-Pong, S and Yu, A. Shargel and Yu's applied biopharmaceutics and pharmacokinetics: Bioavailability and bioequivalence. 8th ed. McGraw Hill: New York, USA, 2022.
Other Information Sources
1	http://www.iupac.org/