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Cell and Tissue Microstructure
Study Course Description
Course Description Statuss:Approved
Course Description Version:6.00
Study Course Accepted:28.03.2022 14:13:02
| Study Course Information | |||||||||
| Course Code: | MK_032 | LQF level: | Level 6 | ||||||
| Credit Points: | 2.00 | ECTS: | 3.00 | ||||||
| Branch of Science: | Clinical Medicine; Histology and Cytology | Target Audience: | Medical Technologies | ||||||
| Study Course Supervisor | |||||||||
| Course Supervisor: | Valērija Groma | ||||||||
| Study Course Implementer | |||||||||
| Structural Unit: | Department of Morphology | ||||||||
| The Head of Structural Unit: | |||||||||
| Contacts: | Riga, 9 Kronvalda boulevard, aaiak rsu[pnkts]lv, +371 67061551 | ||||||||
| Study Course Planning | |||||||||
| Full-Time - Semester No.1 | |||||||||
| Lectures (count) | 7 | Lecture Length (academic hours) | 2 | Total Contact Hours of Lectures | 14 | ||||
| Classes (count) | 6 | Class Length (academic hours) | 3 | Total Contact Hours of Classes | 18 | ||||
| Total Contact Hours | 32 | ||||||||
| Study course description | |||||||||
| Preliminary Knowledge: | Previously acquired knowledge of biology and chemistry. | ||||||||
| Objective: | This course is designed to deepen our knowledge of fundamental cellular and molecular biology problems, to develop practical skills and competences in cell structure microscopical and ultrastructural analysis in the medical engineering sector. The course focuses on the essential principles of cell structure and activities accompanied by a description of commonly used techniques and equipment. This course provides the possibility to combine a theoretical knowledge and practical demonstrations, and increase understanding of the cellular base of physiological and pathological processes and their significance in the study of medical engineering. | ||||||||
| Topic Layout (Full-Time) | |||||||||
| No. | Topic | Type of Implementation | Number | Venue | |||||
| 1 | Diversity of cells. Morphological research methods. | Lectures | 1.00 | Institute of Anatomy and Anthropology | |||||
| 2 | The cell membrane. Molecular transport through membranes. Cytoplasmic organelles. | Lectures | 1.00 | Institute of Anatomy and Anthropology | |||||
| 3 | Epithelial tissue and connective tissue. Tissue barriers in the human body. | Lectures | 1.00 | Institute of Anatomy and Anthropology | |||||
| 4 | Supporting tissues, the dynamic nature and remodeling of supportive tissue. Biocompatibility. | Lectures | 1.00 | Institute of Anatomy and Anthropology | |||||
| 5 | Muscle tissue. Muscle tissue contraction mechanism. Muscle tissue regeneration. | Lectures | 1.00 | Institute of Anatomy and Anthropology | |||||
| 6 | Nervous tissue, structure and functions. The concept of the cell membrane action potential; nerve impulse. Neurotransmitters. | Lectures | 1.00 | Institute of Anatomy and Anthropology | |||||
| 7 | Blood cell morphology; cardiovascular system (heart, blood vessels), the reconstruction, vascular stents. | Lectures | 1.00 | Institute of Anatomy and Anthropology | |||||
| 8 | Diversity of eukaryotic cells; preparation of histological slides; immunocytochemistry, cytochemistry, clinical significance. | Classes | 1.00 | Institute of Anatomy and Anthropology | |||||
| 9 | Method of electron microscopy; semithin and ultrathin sectioning; preparation and analysis. | Classes | 1.00 | Institute of Anatomy and Anthropology | |||||
| 10 | Demonstrations of various epithelia and connective tissue (cornea, skin, intestinal epithelium, loose connective tissue, tendon). | Classes | 1.00 | Institute of Anatomy and Anthropology | |||||
| 11 | Cartilage. | Classes | 1.00 | Institute of Anatomy and Anthropology | |||||
| 12 | Various types of bone, bone implants. | Classes | 1.00 | Institute of Anatomy and Anthropology | |||||
| 13 | Nervous tissue, structure and functions; neural structure of the synapse and neurotransmitters; impulse transmission; myelin; regeneration. | Classes | 1.00 | Institute of Anatomy and Anthropology | |||||
| Assessment | |||||||||
| Unaided Work: | Analysis of the electron and light microscopy micrographs, descriptions of schemes that confirm the understanding of fundamentals of cell biology. Self-studies using literature, making a description of electron micrographs, histological slides, and schemes. Descriptions and contribution to the discussion related to slide analysis. | ||||||||
| Assessment Criteria: | Attendance of practical classes and lecture, practical work during practical class (20%), analysis of histological slides, cellular structures. Participation in a discussion (30%). Written Exam at the end of this study course (50% of evaluation). | ||||||||
| Final Examination (Full-Time): | Exam (Written) | ||||||||
| Final Examination (Part-Time): | |||||||||
| Learning Outcomes | |||||||||
| Knowledge: | Students will be able to describe basic properties of cells and main cell types, history of discovery of the cell, modern methods used for the study of cells, components of biological membranes and their role in the maintenance of cell function, cellular organelles and main events attributed to the cytoplasmatic organelles, tissue adaption, tissue barriers, biocompatibility; cell and tissue examination methods and novel future possibilities. | ||||||||
| Skills: | Using bright-field optics and examining paraffin-embedded tissue sections, students will be able to distinguish the major cell components, will be introduced to commonly used cytological staining techniques; will be able to evaluate a specialized cell shape and size, and structurally based communications, as well as identify major artifacts appearing due to inadequate sample processing. Students will be able to describe and distinguish main tissue groups and organ systems, describe modern morphology methods and their necessary equipment. | ||||||||
| Competencies: | Student will be able to distinguish by the use of a microscope: main tissue groups, structure of the main organs; evaluate quality of a particular slide, interactions and localization of tissue structures within the histological slide; will be able to document cell biology and histology slides and to work with the special literature. | ||||||||
| Bibliography | |||||||||
| No. | Reference | ||||||||
| Required Reading | |||||||||
| 1 | Groma V., Zalcmane V. Šūna: uzbūve, funkcijas, molekulārie pamati. 2012. Rīga, RSU. 284 lpp. Mācību grāmatas autore ir struktūrvienības darbiniece, no latviešu grāmatu klāsta, patlaban vienīgais pieejamais avots./The author of the textbook is an employee of the structural unit, from the range of Latvian books, currently the only available source. | ||||||||
| 2 | Kierszenbaum Abraham L., Tres Laura L. 2019. Histology and Cell Biology: An Introduction to Pathology. 5th Edition. Elsevier. 824 p. ISBN: 9780323673211, eBook ISBN: 9780323683784 | ||||||||
| 3 | Burns E.R., Cave M.D. 2007. Histology and Cell Biology. 2nd Edition. Mosby. 321 p. ISBN-13: 9780323044257, ISBN-10: 0323044255 (akceptējams izdevums/approved publication) | ||||||||
| 4 | Paulsen D.F. 2021. Histology and cell biology: Examination and Board Review. 6th Edition. McGraw Hill/ Medical. 453 p. ISBN 978-1-264-26992-1, ISSN 1045-4586 | ||||||||
| 5 | Allen T. 2015. Microscopy: A Very Short Introduction. Oxford University Press. 144 p. ISBN-13: 978-0198701262, ISBN-10: 9780198701262 | ||||||||
| 6 | Eroschenko Victor P. 2013. diFiore's Atlas of Histology: with Functional Correlations (Atlas of Histology (Di Fiore's)). 12th Edition. LWW. 617 p. ISBN-13: 978-1496316769, ISBN-10: 1496316762 | ||||||||
| 7 | Mescher Anthony L. 2021. Junqueira's Basic Histology: Text and Atlas. 16th Edition. McGraw-Hill Education. 480 p. ISBN-10:1260462986, ISBN-13:978-1260462982 | ||||||||
| 8 | Lowe J., Anderson P., Anderson S. 2018. Stevens & Lowe's Human Histology. 5th Edition. Elsevier. 440 p. ISBN: 9780323612807, ISBN: 9780323612791 | ||||||||
| 9 | Ārvalstu studentiem/For international students: | ||||||||
| 10 | Kierszenbaum Abraham L., Tres Laura L. 2019. Histology and Cell Biology: An Introduction to Pathology. 5th Edition. Elsevier. 824 p. ISBN: 9780323673211, eBook ISBN: 9780323683784 | ||||||||
| 11 | Burns E.R., Cave M.D. 2007. Histology and Cell Biology. 2nd Edition. Mosby. 321 p. ISBN-13: 9780323044257, ISBN-10: 0323044255 (akceptējams izdevums/approved publication) | ||||||||
| 12 | Lowe J., Anderson P., Anderson S. 2018. Stevens & Lowe's Human Histology. 5th Edition. Elsevier. 440 p. ISBN: 9780323612807, ISBN: 9780323612791 | ||||||||
| 13 | Mescher Anthony L. 2021. Junqueira's Basic Histology: Text and Atlas. 16th Edition. McGraw-Hill Education. 480 p. ISBN-10:1260462986, ISBN-13:978-1260462982 | ||||||||
| 14 | Eroschenko Victor P. 2013. diFiore's Atlas of Histology: with Functional Correlations (Atlas of Histology (Di Fiore's)). 12th Edition. LWW. 617 p. ISBN-13: 978-1496316769, ISBN-10: 1496316762 | ||||||||
| Additional Reading | |||||||||
| 1 | Boka S., Pilmane M., Kavak V. 2010. Embryology and anatomy for health sciences. Rīgas Stradiņa universitāte. 404 p. ISBN-10: 9984788504, ISBN-13: 978-9984788500. Mācību grāmatas autore ir struktūrvienības darbiniece, no latviešu grāmatu klāsta, patlaban vienīgais pieejamais avots./The author of the textbook is an employee of the structural unit, from the range of Latvian books, currently the only available source. | ||||||||
| 2 | Young Barbara, O'Dowd Geraldine, Woodford Phillip. 2013. Wheater's Functional Histology: A Text and Colour Atlas. 6th Edition. Churchill Livingstone. 464 p. ISBN-10: 0702047473, ISBN-13: 978-0702047473 | ||||||||
| 3 | Ovalle William K., Nahirney Patrick C. 2020. Netter's Essential Histology. 3rd Edition. Elsevier. 568 p. ISBN-10:0323694640, ISBN-13:978-0323694643 | ||||||||
| Other Information Sources | |||||||||
| 1 | Vrana N. E. 2020. Cell and Material Interface: Advances in Tissue Engineering, Biosensor, Implant, and Imaging Technologies (Devices, Circuits, and Systems). 1st Edition. CRC Press. 294 p. ISBN-13: 978-0367656379, ISBN-10: 036765637X | ||||||||
| 2 | Freeman J. W. , Banerjee D. 2018. Building Tissues: An Engineer's Guide to Regenerative Medicine (Biomedical Engineering). 1st Edition. CRC Press. 233 p. ISBN-13: 978-1498742801, ISBN-10: 1498742807 | ||||||||
