Evaluation of endometrial premalignant and malignant pathologies in the Latvian female population and selection of their prognostic biomarkers for the development of an algorithm

Proliferative processes in the uterine wall are a commonly occurring female reproductive system pathology, with an incidence of up to 50% of women in the general population. Adenomatous endometrial hyperplasia with atypia is considered a premalignant state, since tumours develop in 8%-29% of cases. 54% of endometrial hyperplasia is  discovered accidentally during a standard ultra sonographic examination. Endometrial cancer is the most common of all gynaecological tumours

Early diagnosis of endometrial borderline states and pathogenically-based treatment are fundamental conditions for the prevention of endometrial cancer. It is expected that during this project importance of endometrium premalignant and malignant pathology prognostic biomarkers will be assessed. Identification of cell, molecular and genetic parameters with endocrine risk factors will allow the use of pathogenic-based treatment tactics and judge disease prognosis, which will help to optimise the treatment strategy and tactics

Activities of the project

• Recruitment of patients, conducting of a questionnaire for the collecting of data of anamnesis, creation of a database
• Obtaining of materials from hospitals and their processing, using pathological, molecular pathology and genetic methods
• Morphological analysis of results and the evaluation of the significance of biomarkers in relation to the research of the pathogenic mechanism of the disease
• Reports in congresses and conferences, preparation of publications
• Preparation of lecture excerpts and integration in student and resident study programmes