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Nanoparticle Transfer Through Endothelial Barrier (NanoTENDO)
Project/agreement No.
1.1.1.5/ERANET/20/02
Project funding
600 854.00 EUR, From which 129 910.00 EUR RSU part.
Project manager
Project realization
01.04.2020. - 31.08.2023.
Aim
Aim of present project is to elucidate the mechanisms of transfer through the endothelial barrier for the most promising carbosilane-based NPs: functionalized gold NPs, dendrimers, dendrons and their complexes with drugs and nucleic-acids-based immunomodulators.
Description
Lead partner of the projekt:
- University of Lodz (Poland).
Partners of the projecty:
- Riga Stradiņš University (Latvia),
- University of Alcala, Faculty of Sciences (Spain),
- Latvian Biomedical Research and Study Centre (Latvia).
Project activities:
- Study the uptake and efflux of NPs through the endothelial barrier and their cytotoxicity using molecular and cell biology techniques;
- Estimate the functional state of the endothelial barrier cells in the presence of NPs and their complexes;
- Repeat (1) and (2) under conditions of endothelial barrier stress induced by oxidative stress and acidification (related to brain ischemia) and the presence of amyloid-beta peptides (related to Alzheimer’s disease);
- Establish murine models of brain ischemia and AD; and
- Approve the therapeutic potential of NP complexes of drugs/nucleic acids tested above in in vivo system.
More information: http://nanotendo.pl/
