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Organic Chemistry

Study Course Description

Course Description Statuss:Approved
Course Description Version:1.00
Study Course Accepted:20.03.2024 16:35:03
Study Course Information
Course Code:FKK_047LQF level:Level 7
Credit Points:9.33ECTS:14.00
Branch of Science:ChemistryTarget Audience:Pharmacy
Study Course Supervisor
Course Supervisor:Māra Plotniece
Study Course Implementer
Structural Unit:Department of Pharmaceutical Chemistry
The Head of Structural Unit:
Contacts:16 Dzirciema Street, Room No A-502, farmkkatrsu[pnkts]lv
Study Course Planning
Full-Time - Semester No.1
Lectures (count)10Lecture Length (academic hours)2Total Contact Hours of Lectures20
Classes (count)15Class Length (academic hours)3Total Contact Hours of Classes45
Total Contact Hours65
Full-Time - Semester No.2
Lectures (count)6Lecture Length (academic hours)2Total Contact Hours of Lectures12
Classes (count)14Class Length (academic hours)5Total Contact Hours of Classes70
Total Contact Hours82
Part-Time - Semester No.1
Lectures (count)14Lecture Length (academic hours)4Total Contact Hours of Lectures56
Classes (count)14Class Length (academic hours)4Total Contact Hours of Classes56
Total Contact Hours112
Study course description
Preliminary Knowledge:
Knowledge of organic chemistry within the programme of secondary school, inorganic chemistry, laboratory techniques.
Objective:
Learn basic course of organic chemistry for further understanding of biochemistry, medical chemistry and pharmaceutical science.
Topic Layout (Full-Time)
No.TopicType of ImplementationNumberVenue
1Basic of organic chemistryLectures1.00auditorium
2Seminar: nomenclature of organic compounds. Test: nomenclature of organic compounds.Classes1.00laboratory
3Seminar: acidity and basicity of organic compounds, stereochemistry. Test: acidity and basicity of organic compounds, stereochemistry.Classes1.00laboratory
4Hydrocarbons.Lectures2.00auditorium
5Colloquium: Basic of organic chemistryClasses1.00laboratory
6Practical work: chemical properties and identification reactions of hydrocarbons. Seminar: chemical properties and identification reactions of hydrocarbons. Test: chemical properties and identification reactions of hydrocarbons.Classes2.00laboratory
7Introduction to spectroscopy (IR un 1H NMR spectroscopy for identification of organic compounds)Lectures1.00auditorium
8Organic halides, alcohols, phenols, ethers, sulfur containing compounds.Lectures1.00auditorium
9Colloquium: hydrocarbonsClasses1.00laboratory
10Practical work and seminar: chemical properties and identification reactions of organic halides, alcohols, phenols, ethers, sulfur containing compoundsClasses1.00laboratory
11Colloquium: organic halides, alcohols, phenols, ethers, sulfur containing compounds.Classes1.00laboratory
12Carbonylcompounds: Aldehydes and ketonesLectures1.00auditorium
13Practical work: chemical properties and identification reactions of aldehydes and ketonesClasses1.00laboratory
14Amines, diazonium ions, azocompounds and other nitrogen containing compoundsLectures2.00auditorium
15Colloquium: aldehydes and ketones (carbonylcompounds).Classes1.00laboratory
16Practical work: chemical properties and identification reactions of amines, diazonium ions and azocompounds.Classes1.00laboratory
17Seminar: chemical properties and identification reactions of amines, diazonium ions and azocompounds.Classes1.00laboratory
18Carboxylic acidsLectures1.00auditorium
19Carboxylic acid derivatives, different functional group containing carboxylic acids, derivatives of carbonic acid, sulfonic acids.Lectures1.00auditorium
20Colloquium: amines, diazonium ions and azocompoundsClasses1.00laboratory
22Practical work: chemical properties and identification reactions of carboxylic acids and their derivatives. Seminar: chemical properties and identification reactions of carboxylic acids and their derivatives.Classes1.00laboratory
23Colloquium: carboxylic acids and their derivatives. FINNAL TESTClasses1.00laboratory
24HeterocyclesLectures2.00auditorium
25Practical work: Purification of organic com-pounds: crystallization, fractional distillation, sublimation, extraction. Colloquium: Basic of organic chemistry.Classes2.00laboratory
26Seminar: Heterocycles: clasification and no-menclature, heterocycles with one heteroatom, heterocycles with two heteroatoms, purine, pteridine, alkaloids.Classes1.00laboratory
27Practical work: Synthesis of organic compounds (individual work)Classes3.00laboratory
28Test: HeterocyclesClasses0.50laboratory
29CarbohydratesLectures2.00auditorium
30Colloquium: Heterocycles. Seminar: Carbohydrates.Classes2.00laboratory
31Test: CarbohydratesClasses0.50laboratory
32Colloquium: Carbohydrates.Classes1.00laboratory
33Aminoacids, peptides, nucleic acidsLectures1.00auditorium
34Seminar: Aminoacids, peptides, nucleic acids.Classes1.00laboratory
35Colloquium: Aminoacids, peptides, nucleic acids.Classes0.50laboratory
36Seminar: Lipids. Practical work: Identification of organic compound using chemical and spectroscopic methods.Classes2.00laboratory
37Lipids. Cholesterol.Lectures1.00auditorium
38Colloquium: Lipids, cholesterol.Classes0.50laboratory
Topic Layout (Part-Time)
No.TopicType of ImplementationNumberVenue
1Basic of organic chemistryLectures1.00auditorium
2Seminar: nomenclature of organic compounds. Test: nomenclature of organic compounds.Classes0.50laboratory
3Seminar: acidity and basicity of organic compounds, stereochemistry. Test: acidity and basicity of organic compounds, stereochemistry.Classes0.50laboratory
4Hydrocarbons.Lectures2.00auditorium
6Practical work: chemical properties and identification reactions of hydrocarbons. Seminar: chemical properties and identification reactions of hydrocarbons. Test: chemical properties and identification reactions of hydrocarbons.Classes1.00laboratory
8Organic halides, alcohols, phenols, ethers, sulfur containing compounds.Lectures1.00auditorium
9Colloquium: hydrocarbonsClasses1.00laboratory
10Practical work and seminar: chemical properties and identification reactions of organic halides, alcohols, phenols, ethers, sulfur containing compoundsClasses1.00laboratory
11Colloquium: organic halides, alcohols, phenols, ethers, sulfur containing compounds.Classes1.00laboratory
12Carbonylcompounds: Aldehydes and ketonesLectures1.00auditorium
13Practical work: chemical properties and identification reactions of aldehydes and ketonesClasses0.50laboratory
14Amines, diazonium ions, azocompounds and other nitrogen containing compoundsLectures1.50auditorium
15Colloquium: aldehydes and ketones (carbonylcompounds).Classes1.00laboratory
16Practical work: chemical properties and identification reactions of amines, diazonium ions and azocompounds.Classes1.00laboratory
17Seminar: chemical properties and identification reactions of amines, diazonium ions and azocompounds.Classes1.00laboratory
18Carboxylic acidsLectures1.00auditorium
19Carboxylic acid derivatives, different functional group containing carboxylic acids, derivatives of carbonic acid, sulfonic acids.Lectures1.00auditorium
21Dicarboxylic acidsLectures0.50auditorium
22Practical work: chemical properties and identification reactions of carboxylic acids and their derivatives. Seminar: chemical properties and identification reactions of carboxylic acids and their derivatives.Classes0.50laboratory
23Colloquium: carboxylic acids and their derivatives. FINNAL TESTClasses1.00laboratory
24HeterocyclesLectures1.50auditorium
26Seminar: Heterocycles: clasification and no-menclature, heterocycles with one heteroatom, heterocycles with two heteroatoms, purine, pteridine, alkaloids.Classes1.00laboratory
29CarbohydratesLectures1.50auditorium
30Colloquium: Heterocycles. Seminar: Carbohydrates.Classes0.50laboratory
32Colloquium: Carbohydrates.Classes1.00laboratory
33Aminoacids, peptides, nucleic acidsLectures1.00auditorium
35Colloquium: Aminoacids, peptides, nucleic acids.Classes1.00laboratory
37Lipids. Cholesterol.Lectures1.00auditorium
38Colloquium: Lipids, cholesterol.Classes0.50laboratory
Assessment
Unaided Work:
Individual laboratory experiments, problem solving, preparation, presentation and defence of literature research on specific drug substance. Individual work with home tasks, laboratory work protocol processing, studying of lecture materials. It is recommended to fill in the study course survey, evaluating the existing course content and creating proposals for updating the course.
Assessment Criteria:
1. Knowledge evaluation during practical sessions – discussions, seminars, colloquia, evaluation of results of experimental work; 2. Application of theoretical knowledge in practical tasks; 3. Assessment of student's attitude (activity in seminars, ability to improve knowledge, ability to work in a team explaining to others, attendance); 4. Analysis of unknown substance at the end of semester 3, performing various reactions and drawing conclusions on the presence of functional groups in the molecule; 5. Semester test at the end of the 2nd semester; 6. Written examination at the end of the 3rd semester.
Final Examination (Full-Time):Exam (Written)
Final Examination (Part-Time):Exam (Written)
Learning Outcomes
Knowledge:On successful course completion students will: • identify functional groups of organic compounds and explain their properties and possibilities of mutual conversions; • interpret relations of special structures of molecules with their properties; • identify structures of heterocyclic compounds and their properties; • interpret reactions of organic compounds on the bases of the main principles of reaction mechanisms.
Skills:On successful course completion students will: • recognize functional groups in drug molecules, name them, know the chemical properties and identification reactions of the group; • select and apply correct methods for isolation and purification of organic compounds; • evaluate chemical structures of drug substances in connection with their pharmacological actions.
Competencies:On successful course completion students will choose and interpret chemical and physical methods of identification and functional analysis of organic compounds.
Bibliography
No.Reference
Required Reading
1P.M. Dewick. Essentiasl of Organic Chemistry. John Wiley & Son’s, England, 2006. (akceptējams izdevums)
2K.P.C. Vollhardt, N.E. Shore. Organic Chemistry: Structure and Function. 7th ed. New York, N.Y. : W.H. Freeman and Company, 2014.
3Органическая химия. Книга 1. Подред. Н.А. Тюкавкиной. М. 2003. (akceptējams izdevums)
4Органическая химия. Книга 2.Спец.курсс. Подред. Н.А. Тюкавкиной. М. 2009. (akceptējams izdevums)
5T.W. Graham Solomons. Solomons' Organic Chemistry. University of South Florida, 2017.
Additional Reading
1R. Valters. Organiskā ķīmija (speckurss). RTU Rīga, 2009
2R. Valters. Heterociklisko savienojumu ķīmija. RTU Rīga, 1995.
3R. Valters. Kodolu magnētiskās rezonanses spektroskopija. RTU Rīga, 2008.
4V. Alagarsamy. Pharmaceutical Organic Chemistry. BSP BOOKS, 2020, e-book.
5Rawn, J. David; Ouellette, Robert J. Organic Chemistry: structure, mechanism, and synthesis. 1st ed. San Diego, CA : Elsevier. 2014. eBook.
6Тюкавкина Н.А. Бауков Ю.И. Биоорганическая химия. М. 1991.
7Armarego, W. L. F.; Chai, Christina Li Lin. Purification of laboratory chemicals. 6th ed. Oxford : Butterworth-Heinemann. 2012. eBook.
8Ārvalstu studentiem/For international students
9V. Alagarsamy. Pharmaceutical Organic Chemistry. BSP BOOKS, 2020, e-book.
10Armarego, W. L. F.; Chai, Christina Li Lin. Purification of laboratory chemicals. 6th ed. Oxford : Butterworth-Heinemann. 2012. eBook.