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Work experience

2016 - Present

Researcher

Latvian Biomedical Research and Study Centre

2014 - Present

Assistant Professor

Faculty of Medicine, Department of Human Physiology and Biochemistry

2014 - 2016

Researcher

Latvian Institute of Organic Synthesis

2013 - 2014

Lecturer

Faculty of Medicine, Department of Human Physiology and Biochemistry

2012 - 2013

Assistant

Faculty of Medicine, Department of Human Physiology and Biochemistry

2009 - 2013

Research assistant

Latvian Biomedical Research and Study Centre

2008 - 2009

Assistant

Latvian Biomedical Research and Study Centre

Education and training

2014

Dr. biol., subfield molecular biology

University of Latvia

2008 - 2011

PhD studies, faculty of Pharmacy

Rīga Stradiņš University

2002 - 2007

Master of Pharmacy/ Pharmacist

Rīga Stradiņš University

Achievements

Continuing education a.o. qualification upgrade

Practical courses. FEBS practical and lecture course on modern methods of protein crystallography "BioCrys 2012", Portugal, Oeiras, 2012.

Practical courses​. Oulu university practical course on protein crystallography "From data to structures", Finland, Oulu, 2012.

Practical courses​. EMBO practical course "Computational structural biology – from data to structure to function", UK, Hinxton, 2011.

Practical courses. ​EMBO practical course "High-throughput methods for Protein Production and Crystallization", France, Marseille, 2011.

Practical courses. ​EMBO/EMBL practical course Protein expression, purification and crystallisation, Germany, Hamburg, 2010.

Field of research

  • Molecular biology
  • Structural biology

Head of study course

Medical biochemistry

Lectured study course

Biochemistry

Biochemistry of Different Pathologies

Cell Metabolism

Medical Biochemistry

Preclinical Dismetabolism

Supervised and reviewed student research papers

Supervised:

Master's theses: 3

qualification papers: 7

Reviewed:

PhD theses: 2

Master's theses: 2

qualification papers: 3

Projects

Researcher, ERDF grant Nr. 1.1.1.2/VIAA/1/16/144 "Structural and functional studies of Lyme disease agent Borrelia burgdorferi outer surface proteins to reveal the mechanisms of pathogenesis with the intention to create a new vaccine".

Researcher, EC 7th Framework Programme project REGPOT-CT-2013-316149-InnovaBalt, „Strengthening the research and innovative capacities of the Latvian Institute of Organic Synthesis, the leading Baltic regional centre for drug discovery".

Research assistant, ERDF grant 2DP/2.1.1.1.0/10/APIA/VIAA/022, „Development and validation of novel DNA tests for diagnosis applicable in clinical practice".

Research assistant, ​ESF grant 1DP/1.1.1.2.0/09/APIA/VIAA/150, „The investigation of molecular and genetic mechanisms of pathogenesis and the development of novel means for diagnosis and therapy".

Supervised study course

Medical Biochemistry

Publications

Research articles​​

Crystal structure of the N-terminal domain of the major virulence factor BB0323 from the Lyme disease agent Borrelia burgdorferi / K.Brangulis, I.Akopjana, A.Kazaks, K.Tars // Acta Crystallographica. Sect.D. Structural Biology. - Vol.75, Part 9 (2019, Sept.), p.825-830. - Web of Science un/vai Scopus. - DOI: 10.1107/S2059798319010751

Crystal structure of Borrelia burgdorferi outer surface protein BBA69 in comparison to the paralogous protein CspA / K.Brangulis, I.Akopjana, I.Petrovskis ...[u.c.] // Ticks and Tick-borne Diseases. - Vol.10, No.5 (2019, Aug.), p.1135-1141. - Web of Science un/vai Scopus. - 10.1016/j.ttbdis.2019.06.009

Crystal structure of the membrane attack complex assembly inhibitor BGA71 from Lyme disease agent Borrelia bavariensis [Elektroniskais resurss] / K.Brangulis, I.Akopjana, I.Petrovskis ...[et al.] // Scientific Reports [Elektroniskais resurss]. - Vol.8 (2018, July), article No.11286, [11 p.]. - Pieejas veids: Tīmeklis WWW.URL: https://www.nature.com/articles/s41598-018-29651-9.pdf

Crystal structures of the Erp protein family members ErpP and ErpC from Borrelia burgdorferi reveal the reason for different affinities for complement regulator factor H. / K.Brangulis, I.Petrovskis, A.Kazaks ...[et al.] // Biochimica et Biophysica Acta. - Vol.1854, No.4 (2015, May), p.349-355. - Starptautiski citējamā izdevumā.

Structural and functional analysis of BB0689 from Borrelia burgdorferi, a member of the bacterial CAP superfamily / K.Brangulis, K.Jaudzems, I.Petrovskis ...[et al.] // Journal of Structural Biology. - Vol.192, No.3 (2015, Dec.), p.320-330. - Starptautiski citējamā izdevumā.

Crystal structure of the infectious phenotype-associated outer surface protein BBA66 from the Lyme disease agent Borrelia burgdorferi / K.Brangulis, I.Petrovskis, R.Ranka...[et al.] // Ticks and Tick-borne Diseases. - Vol.5, No.1 (2014, Febr.), p.63-68. - Starptautiski citējamā izdevumā.

Structural characterization of CspZ, a complement regulator factor H and FHL-1 binding protein from Borrelia burgdorferi / K.Brangulis, I.Petrovskis, R.Ranka ...[et al.] // The FEBS Journal. - Vol.281, No.11 (2014, June), p.2613-2622. - Starptautiski citējamā izdevumā.

Analysis of seroreactivity to recombinant B. burgdorferi antigens BBA65 and BBA73 / R.Ranka, K.Brangulis, D.Bandere ...[et al.] // Collection of Scientific Papers 2014 : Research articles in medicine & pharmacy / Rīga Stradiņš University. - Riga, 2014. - P.40-46.

Fibronectin-binding nanoparticles for intracellular targeting addressed by B. burgdorferi BBK32 protein fragments / R.Ranka, K.Brangulis, I.Petrovskis ...[et al.] // Nanomedicine : Nanotechnology, Biology, and Medicine. - Vol.9, No.1 (2013, Jan.), p.65-73. - Starptautiski citējamā izdevumā.

Structural characterization of the Borrelia burgdorferi outer surface protein BBA73 implicates dimerization as a functional mechanism / K.Brangulis, I.Petrovskis, A.Kazaks ...[et al.] // Biochemical and Biophysical Research Communications. - Vol.434, No.4 (2013, May), p.848-853. - Starptautiski citējamā izdevumā.

Structure of an outer surface lipoprotein BBA64 from the Lyme disease agent Borrelia burgdorferi which is critical to ensure infection after a tick bite / K.Brangulis, K.Tars, R.Ranka ...[et al.] // Acta Crystallographica. Sect.D. Biological Crystallography. - Vol.69, No.6 (2013, June), p.1099-1107. - Starptautiski citējamā izdevumā.

Abstracts​​

Brangulis, Kalvis. Crystal structure of Borrelia burgdorferi outer surface protein BBA69 / K.Brangulis // 4th Instruct Biennial Structural Biology Conference "Structural biology: deeper into the cell" (Madrid, Spain, May 22-24, 2019) : Abstract Booklet. - Madrid, 2019. - Poster No.60, p.100.

Crystal structure of BB0365 from Lyme agent Borrelia burgdorferi / K.Brangulis, I.Akopjana, I.Petrovskis ...[et al.] // 13th International Symposium on Ticks and Tick-Borne Diseases (Weimar, Germany, March 28-30, 2019) : Programme & Abstract Book. - Weimar, 2019. - P.84.

Crystal structure of Borrelia burgdorferi outer surface protein BBK01 – a member of the paralogous gene family 12 / K.Brangulis, I.Akopjana, A.Kazaks, K.Tars // FEBS Open Bio. - Vol.9, Suppl.1 (2019, July), poster No.P-27-064, p.267. - The 44th FEBS Congress (Krakow, Poland, July 6-11, 2019) : Posters.

Crystal structure of the membrane attack complex assembly inhibitor BGA71 from Lyme disease agent Borrelia bavariensis [Elektroniskais resurss] / K.Brangulis, I.Akopjana, I.Petrovskis ...[et al.] // FEBS Open Bio [Elektroniskais resurss]. - Vol.8, Suppl.1 (2018, July), p.441. - 43rd FEBS Congress "Biochemistry forever" (Prague, Czech Republik, July 7-12, 2018) : Abstracts. - Pieejas veids: Tīmeklis WWW.URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031936/pdf/FE…- Starptautiski citējamā izdevumā.

The crystal structure of Lyme disease agent Borrelia burgdorferi surface protein BBE31 that is vital for successful colonization of a mammalian host [Elektroniskais resurss] / K.Brangulis, I.Akopjana, I.Petrovskis ...[et al.] // The FEBS Journal [Elektroniskais resurss]. - Vol.284, Issue Suppl.S1 (2017, Sept.), p.132-133. - Starptautiski citējamā izdevumā. - Pieejas veids: Tīmeklis WWW.URL: http://onlinelibrary.wiley.com/doi/10.1111/febs.14174/epdf

Study of B. burgdorferi outer membrane proteins by protein-protein interaction approach / R.Ranka, K.Brangulis, V.Baumanis ...[et al.] // The FEBS Journal. - Vol.280, Suppl.1 (2013, July.), p.490. - Starptautiski citējamā izdevumā.

Successful creation of chimeric virus-like particles maintaining fibronectin-binding property from B. burgdorferi BBK32 protein [Elektroniskais resurss] : [abstract] / R.Ranka, K.Brangulis, V.Baumanis ...[et al.] // XII International Jena Symposium on Tick-borne Diseases (Weimar, Germany, March 21-23, 2013) [Elektroniskais resurss]. - Weimar, 2013. - Poster No.59. - Resurss aprakstīts 2014.g. 27.febr. - Pieejas veids: Tīmeklis WWW.URL: http://www.tbd-symposium.com/media/public/abs_ijstd_xii/P59…

Objects of intellectual property rights

Coupling of Borrelial protein BB0689 to virus-like particles for generation of Lyme disease vaccine : EP3135295 (A1) : international patent / inventors: K.Tars, I.Petrovskis, K.Brangulis ...[et al.]. - Filing date: 28.08.2015 ; publication date: 01.03.2017.

Contacts

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