Biochemistry in Dentistry

Study Course Description

Course Description Statuss:Approved

Course Description Version:2.00

Study Course Accepted:22.08.2022 10:25:00

Study Course Information
Course Code:		CFUBK_074		LQF level:		Level 7
Credit Points:		2.00		ECTS:		3.00
Branch of Science:		Clinical Medicine; Medical Biochemistry		Target Audience:		Dentistry
Study Course Supervisor
Course Supervisor:		Kalvis Brangulis
Study Course Implementer
Structural Unit:		Department of Human Physiology and Biochemistry
The Head of Structural Unit:
Contacts:		Riga, 16 Dzirciema Street, cfbkrsu[pnkts]lv, +371 67061550
Study Course Planning
Full-Time - Semester No.1
Lectures (count)		8	Lecture Length (academic hours)		2	Total Contact Hours of Lectures		16
Classes (count)		4	Class Length (academic hours)		4	Total Contact Hours of Classes		16
Total Contact Hours								32
Study course description
Preliminary Knowledge:
Course Medical Biochemistry: CFUBK_005.
Objective:
To provide theoretical and practical knowledge of biochemical processes (digestion and metabolism) occurring in human organism on a molecular level. To facilitate the understanding of regulatory mechanisms of biochemical processes (with emphasis on carbohydrates) both on molecular and on physiological level. To elucidate the role of tissue specific proteins (extracellular matrix and connective tissue) differences in and specific adaptations of biochemical processes in various tissues/organs (cell metabolism). To elucidate biochemical processes related to the health of teeth and mouth.
Topic Layout (Full-Time)
No.	Topic			Type of Implementation		Number	Venue
1	Macromolecules. Digestion of carbohydrates, related pathologies.			Lectures		1.00	auditorium
2	Macromolecules. Digestion of peptides and lipids, related pathologies.			Lectures		1.00	auditorium
3	Hydrolysis of nutrients, peptide chain cleavage, diseases related to digestion.			Classes		1.00	auditorium
4	Bioenergetics, role of ATP in human metabolism, electron transport chain (ETC) and oxidative phosphorylation.			Lectures		1.00	auditorium
5	Glycolysis (aerobic and anaerobic) relation to other major metabolic processes.			Lectures		1.00	auditorium
6	Oxidative stress, activators and inhibitors of ETC, anaerobic glycolysis, lactic acidosis – causes and treatments.			Classes		1.00	auditorium
7	Hormonal regulation of carbohydrate, lipid and amino acid metabolism.			Lectures		1.00	auditorium
8	Fuel metabolism in absorption and postabsorption period, and during exercise.			Classes		1.00	auditorium
9	Tissue proteins – extracellular matrix and connective tissue.			Lectures		1.00	auditorium
10	Biochemistry of teeth, saliva and dental caries, fluoride and fluorosis.			Lectures		1.00	auditorium
11	Proteomics of human saliva and teeth.			Lectures		1.00	auditorium
12	Presentations: novelty of the year in dental biochemistry.			Classes		1.00	auditorium
Assessment
Unaided Work:
Study course includes 48 hours of independent studies, 12 of those is going to be organized work for preparation of presentations. The rest of 36 hours include: • independent studies of sources provided in e-studies (books, review articles); • preparation of homework assigned in e-studies prepared for each seminar; • scientific article analysis; • preparation for an exam.
Assessment Criteria:
Examination (final assessment) includes general multiple choice questions in all topics covered during study course; multiple written tasks covering most important digestion and metabolism processes; written tasks which are designed to evaluate general understanding of relations between biochemical processes and health of mouth and teeth.
Final Examination (Full-Time):		Exam (Written)
Final Examination (Part-Time):
Learning Outcomes
Knowledge:		On completion of the study course students will be able to: • explain and describe digestion of proteins, lipids, nucleic acids, and carbohydrates and related pathologies; • name factors influencing enzyme’s activity; • characterise metabolic pathways in human metabolism that connect carbohydrates, lipids and amino acids and allow these groups to transform into each other, name hormones that regulate these transformations; • name and explain complications related to dysfunction of biochemical pathways studied in the course (e.g. lactoacidosis and ketoacidosis); • name and explain biochemical processes and specific adaptations of connective tissues; • name and explain biochemical processes that ensure the health of mouth and teeth.
Skills:		1. Use of knowledge – ability to explain: • based on enzyme action mechanism, how enzymes activity is influenced by various factors; • the regulation of basic biochemical pathways and their role in the health of mouth and teeth; • the role of proteomics in dentistry. 2. Problem solving skills. 3. Skills to use scientific literature as a source of information. 4. Communication skills gained through organized team work.
Competencies:		On completion of the study course students will be able to: • assess possible disturbances in digestion and their relation to health of mouth and teeth; • assess possible disturbances in metabolic processes and their relation to health of mouth and teeth.
Bibliography
No.	Reference
Required Reading
1	DM Vasudevan, S Sreekumari, Kannan Vaidyanathan. 2017. Textbook of Biochemistry for Dental Students, 3rd Edition
2	Lieberman, M.A. and Peet, A. 2018. Marks' Basic Medical Biochemistry. 4th ed. Lippincott Williams& Wilkins
3	Nelson, D. L. and Cox, M. M. 2017. Lehninger Principles of Biochemistry. 6th ed. New York: W. H. Freeman & Co (or a newer version).
Additional Reading
1	Baynes, J. W., Dominiczak, M. H. 2019. Medical Biochemistry. 4th ed.