Jeļena Krasiļņikova

Work experience

Education and training

Achievements

Continuing education a.o. qualification upgrade

2015

Teaching program by the ERASMUS, Prague, Chech rep.

/Prof. Jaroslav Havlik/. (Five days). Certificates

2012, 2013, 2014

Teaching program by the ERASMUS, Limoge University, Dpt. of Pharmacology, France / Prof. Patrick Trouillas/. (Five days). Certificates.

2010

Staff -Training by the ERASMUS Program, Wallenberg Laboratory Cardiovascular and Metabolic Research, University of Gothenburg, Sweden / Prof. L.Hulten/. (Seven days). Certificate.

2009

Roche Diagnostics Symposium: MipTec Drug Discovery Conf.,

14 oct. Basel, Switzerland. (One day). Certificate.

2009

Staff -Training by the ERASMUS Program, University College of Dublin,

Dpt . of Innovation, Ireland / Prof. M. Keane/.( Seven days). Certificate.

2009

Staff- Training by the ERASMUS Program, Oslo University, Dpt. of Nutrition,

Norway /Prof. R.Blomhoff/. (Seven days). Certificate.

2008

Staff- Training by the ERASMUS Program, Roskilde University,

Denmark./Prof.Ole Vang/. /. (Seven days). Certificate.

2008

Staff -Training by the ERASMUS Program, Reus University, Institute of

Atherosclerosis, Spain /Prof. A.Llobet/. (Seven days). Certificate.

2007

Traditional Chinese Medicine, Beijing University by

Chinese and Latvian Health Ministries supp. Diploma. (3-month course).

1998

Training course "Parenteral and Enteral Nutrition & European Society", ESPEN

Congress, Nice, France. (3 days). Certificate.

1997 – 1998

Training course"Fitness and Nutrition", ICS, USA, Diploma. (One year).

1998

Practical Education Seminar "Nutritional Supplement in the Health and

Pathology", Centre of the Alternative Medicine,"Unicare Inc.",New-Jersy, USA.

Conferences and Seminars

​2016

"Influence of diferent Oregonins on Pancreatic Lipase Activity", RSU Scientific Conference. 17 – 18.03, Riga, Latvia. Personal presentation

2015

"1st POSITIVe Scientific Workshop". "Alcaline table water AQUALAR action on amylase in model". 26 – 27 October, Tour, France

2015

"COST Action FA 1403 Interindividual variation in response to consumption of plant foods bioactives and determinants involved". "Study Design.".22 – 23 Sept., Murcia, Spain.

2015

"VII Latvian Gastroenthology Congress with International participation". "Effects of alkaline water on digestive enzymatic systems". Riga, Latvia.

2015

"4th International Conference on Food Digestion", FA 1005, INFOGEST. "Effects of two types of red wines on the function of the digestive system".

17 – 19 March, Naples, Italy

2014

"2nd International Conference of Nutrition and Growth". "Effect of micro and macrodoses of polyphenols on amylase and lipase activity in the model digestion". 30.01 – 01.02, Barcelona, Spain

2013

"Action FA 1005 Infogest". "Activation of pepsin by proantocyanidins rich compounds in vitro". 18.11, Izmir, Turkey.

2012

"International Conference on Nutrition and Growth". "Perspective of obesity and obesity-associated disorders correction with oregonin". 1 – 3 March, Paris, France

2011

4th Intern.Congress"Myology-2011", Lille, France. Presentation: "Effect of Alder /Alnus Incana/

Diarilheptanoid OREGONIN in Cardiomiopathy of different types". Certificate.

2011

Annual Meeting and Work shop COST Action 0804"Chemical Biology with Natural Products"

Presentation: Functional activity of Alnus Incana hydrophilic extracts with different diarylheptanoids concentration, Dublin, Ireland.

Field of research

• Ethnopharmacology: polyphenols action on metabolism and digestion
• Enzymology
• Degenerative disorders: Lipid and Protein oxidation; metabolic food in various pathologies; design of drugs.

Keywords: Antioxidants - Trace-Elements, Enzymes, Free Radicals and Age-related diseases, Aging markers, Metabolic Food, Dysmetabolism, Lignins, Diarhylheptanoids.

Objects of intellectual property

Malabsorbcijas sindroma ārstēšanas efektivitātes noteikšanas paņēmiens vecāka gadagājuma cilvēkiem : LV 14816 B : patents / izgudrotāji: J.Krasiļņikova, I.Fizdels, M.Fradins, E.Bagirov. - Pieteikts: 26.11.2013 ; publicēts: 20.06.2014. // Izgudrojumi, Preču Zīmes un Dizainparaugi. - Nr.6 (2014), 772.lpp.

Līdzeklis karbonila olbaltumvielu līmeņa pazemināšanai asins plazmā : LV 14615 B : patents / izgudrotāji: J.Krasiļņikova, G.Teliševa, T.Dižbite ...[u.c.]. - Pieteikts: 25.09.2012 ; publicēts: 20.03.2013. // Patenti un Preču Zīmes. - Nr.3 (2013), 309.lpp.

Holestātiskā sindroma ārstēšanas efektivitātes noteikšanas paņēmiens gados vecākiem pacientiem : LV 14411 B : patents / izgudrotāji: J.Krasiļņikova, M.Girgensone, V.Baidak ...[u.c.]. - Pieteikts: 30.06.2011 ; publicēts: 20.07.2012. // Patenti un Preču Zīmes. - Nr.7 (2012), 949.lpp.

Līdzeklis bifidobaktēriju un laktobaktēriju satura paaugstināšanai tievās zarnas gļotādā un pretinfekcijas aizsardzības imūno mehānismu stimulēšanai : LV 14569 B : patents / izgudrotāji: J.Krasiļņikova, G.Teliševa, T.Dižbite ...[u.c.]. - Pieteikts: 30.05.2012 ; publicēts: 20.12.2012. // Patenti un Preču Zīmes. - Nr.11 (2012), 1691.-1692.lpp.

Līdzeklis malondialdehīda (MDA) koncentrācijas pazemināšanai asins plazmā : LV 14499 B : patents / izgudrotāji: G.Teliševa, J.Krasiļņikova, M.Girgensone ...[u.c.]. - Pieteikts: 30.11.2011 ; publicēts: 20.07.2012. // Patenti un Preču Zīmes. - Nr.7 (2012), 952.-953.lpp.

Sirds asinsvadu patoloģijas efektīvas ārstēšanas noteikšanas paņēmiens gados vecākiem cilvēkiem ar 2. tipa cukura diabētu : LV 14437 B : patents / izgudrotāji: J.Krasiļņikova, M.Girgensone, V.Baidak ...[u.c.]. - Pieteikts: 29.04.2011 ; publicēts: 20.11.2012. // Patenti un Preču Zīmes. - Nr.11 (2012), 1522.lpp.

Dismetaboliskās aptaukošanās ārstēšanas efektivitātes noteikšanas paņēmiens : LV 14298 B : patents / izgudrotāji: J.Krasiļņikova, M.Girgensone, E.Bagirov ...[u.c.]. - Pieteikts: 29.11.2010 ; publicēts: 20.12.2011.

Līdzeklis fagocitārās aktivitātes paaugstināšanai : LV 14361 B : patents / izgudrotāji: J.Krasiļņikova, M.Girgensone, G.Teliševa ...[u.c.]. - Pieteikts: 10.03.2011 ; publicēts: 20.11.2011.

Sirds kreisā kambara hipertrofijas ārstēšanas efektivitātes noteikšanas metode hipertonijas gadījumā vecāka gadagājuma cilvēkiem ar 2. pakāpes aptaukošanos : LV 14299 B : patents / izgudrotāji: J.Krasiļņikova, M.Girgensone, E.Bagirov ...[u.c.]. - Pieteikts: 14.12.2010 ; publicēts: 20.12.2011.

Eritrocītu hemoglobīna līmeni paaugstinošs līdzeklis : LV 14012 B : patents / izgudrotāji: J.Krasiļņikova, M.Girgensone, G.Teliševa ...[u.c.]. - Pieteikts: 20.04.2009 ; publicēts: 20.01.2010.

Hroniska bronhīta ārstēšanas efektivitātes noteikšanas paņēmiens : LV 14222 B : patents / izgudrotāji: J.Krasiļņikova, M.Girgensone, E.Bagirovs ...[u.c.]. - Pieteikts: 12.07.2010 ; publicēts: 20.12.2010.

Hroniska gastrīta unatviļņa-ezofagīta efektīvas ārstēšanas noteikšanas paņēmiens : LV 14065 B : patents / izgudrotāji: J.Krasiļņikova, M.Girgensone, E.Bagirovs ...[u.c.]. - Pieteikts: 09.09.2009 ; publicēts: 20.03.2010.

Mutes dobuma gļotādas un periodonta audu saslimšanas ārstēšanas efektivitātes noteikšanas paņēmiens : LV 14044 B : patents / izgudrotāji: J.Krasiļņikova, M.Girgensone, E.Bagirovs ...[u.c.]. - Pieteikts: 01.09.2009 ; publicēts: 20.03.2010.

Pankreatiskās lipāzes aktivitātes asinīs inhibējoša līdzeklis : LV 14193 B : patents / izgudrotāji: J.Krasiļņikova, M.Girgensone, G.Teliševa ...[u.c.]. - Pieteikts: 19.02.2009 ; publicēts: 20.12.2010.

Preparāts, kas paaugstina glutationa līmeni asinīs : LV 14172 B : patents / izgudrotāji: J.Krasiļņikova, M.Girgensone, G.Teliševa ...[u.c.]. - Pieteikts: 11.12.2008 ; publicēts: 20.08.2010.

Triglicerīdu koncentrāciju asins plazmā pazeminošs līdzeklis : LV 14030 B : patents / izgudrotāji: J.Krasiļņikova, M.Girgensone, G.Teliševa ...[u.c.]. - Pieteikts: 04.06.2009 ; publicēts: 20.02.2010.

Supervised study programme

RSU, Professional Development programm "Medicine", Faculty of Continuing Education (Open University)

Head of the study programme

RSU, "Nutrition", RFU and RFUN

RSU, "Sport Biochemistry", VSS

RSU, "Biochemistry", ASNMF

Supervised study course

• RSU, Elective course "Cell Metabolism", 2nd study year, ASNMF and MF
• RSU, Elective course "Pre-clinical Dismetabolism", 3rd study year, ASNMF and MF​
• RSU, Elective course "Medical Biochemistry in Different Pathologies", 6th study year, ASNMF and MF​

Head of study course

• RSU, Elective course "Cell Metabolism", 2nd study year, ASNMF
• RSU, Elective course "Pre-clinical Dismetabolism", 3rd study year, ASNMF
• RSU, Elective course "Medical Biochemistry in Different Pathologies", 6th study year, ASNMF

Lectured study course

• RSU, Elective course "Cell Metabolism", 2nd study year, ASNMF
• RSU, Elective course "Pre-clinical Dismetabolism", 3rd study year, ASNMF
• RSU, Elective course "Medical Biochemistry in Different Pathologies", 6th study year, ASNMF

Supervised and reviewed student research papers

First and second study year medical faculty ​students research works in the COST and Medical Biochemistry Student's Society framework (30 - 80 per year)

Projects

Latvian project:

• State program Nr. 6 ResProd Project: Biomaterials and Bioproducts from Forest resources.

• Latvian/France project "OSMOZE" (2014 - 2015)

International projects:

• WOODWISDOM – Net/ERA – NET projekts „Pinosylvins Novel Bioacive Agents for Food Applications (PINOBIO, 2011 -2014)
• COST FA 1005 INFOGEST (2011-2015)
• COST FA 1403 „POSITIVE" (2013- 2016.)
• COST CM 0804 (2009 - 2013)
• COST BM 0602 (2009 - 2011)​

Memberships

• Representative member of Latvia in European COST Program FA 1005
• Representative member of Latvia in European COST Program CM 0804
• Representative member of Latvia in European COST Program BM 0602
• Adipose tissue: A key target for prevention of the Metabolic Syndrome (2009 - 2011).
• Euroexpert of EU Commission/ Continuing Medical Education System/- TAIEX

Awards and recognitions

RSU Appreciation of a significant investment in the training of students and scientific activities, as well as honoring the 50-year life.

References

• Jānis Gardovskis Prof., Rector of Riga Stradin University; Ph.: +371 67409232; e-mail: Janis[pnkts]Gardovskisrsu[pnkts]lv (Janis[dot]Gardovskis[at]rsu[dot]lv)
• Patrick Trouillas EA4021 Faculte de Pharmacie, 2rue du Docteur Marcland 87025 Limoges Cedex; Ph.: +33(0)555435927; e-mail: Patrick[pnkts]Trouillasunieim[pnkts]fr (Patrick[dot]Trouillas[at]unieim[dot]fr)
• Jaroslav Havlik Ph.D. Research Assistant; University if Glasgow; 3.85 Human Nutrition Section New Lister Building; Alexandra Parade Glasgow G31 2ER; Ph.: 07522670120; e-mail: Jaroslav[pnkts]Havlikglasgow[pnkts]ac[pnkts]uk (Jaroslav[dot]Havlik[at]glasgow[dot]ac[dot]uk)
• Prof. L. Hulten Gothenburg University; Ph: +46313422960, e-mail: lillemor[pnkts]mattssonwlab[pnkts]gu[pnkts]se (lillemor[dot]mattsson[at]wlab[dot]gu[dot]se)​

Publications

Research articles​​

Oregonin reduces lipid accumulation and proinflammatory responses in primary human macrophages / A.Lundqvist, L.U.Magnusson, J.Krasilnikova ...[et al.] // Biochemical and Biophysical Research Communications. - Vol.458, No.3 (2015, March), p.693-699. - Starptautiski citējamā izdevumā.

Elucidation of antioxidant properties of wood bark derived saturated diarylheptanoids : a comprehensive (DFT-supported) understanding / J.Ponomarenko, P.Trouillas, J.Krasilnikova ...[et al.] // Phytochemistry. - Vol.103 (2014, July), p.178-187. - Starptautiski citējamā izdevumā.

Latvijas koku sugu mizas valorizācija fitoķimikāliju un biomateriālu ar pievienoto vērtību ieguvei = Valorization of bark of tree species spread in Latvia as a source for obtaining high value added phytochemicals and bio-based materials / J.Krasiļņikova, G.Teliševa, T.Dižbite ...[u.c.] // Vietējo resursu (zemes dzīļu, meža, pārtikas un transporta) ilgtspējīga izmantošana - jauni produkti un tehnoloģijas (NatRes): valsts pētījumu programma, 2010-2013 : rakstu krājums / sast. B.Andersons ...[u.c.]. - Rīga, 2013. - 136.-139.lpp.

Effect of the plant originated diarylheptanoid oregonin on some antioxidant and lipid peroxidation human blood markers / J.Krasilnikova, M.Girgensone, G.Telysheva ...[et al.] // Collection of Scientific Papers 2010 : Research articles in medicine & pharmacy / Rīga Stradiņš University. - Riga, 2011. - P.134-138.

Structure and antioxidant activity of diarylheptanoids extracted from bark of grey alder (Alnus incana) and potential of biorefinery-based bark processing of European trees / J.Krasilnikova, G.Telysheva, T.Dizhbite ...[et al.] // Holzforschung. - Vol.65, N 4 (2011, June), p.623-629. - Starptautiski citējamā izdevumā.

Biorefinery for bark of deciduous trees / G.Telysheva, T.Dizhbite, J.Krasilnikova ...[et al.] // 11th European Workshop on Lignocellulosics and Pulp (Hamburg, Germany, Aug.16-19, 2010) : Proceedings. - Hamburg, 2010. - P.77-80.

Abstracts​​

Influence of different oregonins on pancreatic lipase activity / J.Krasilnikova, M.Zalomonson, T.Doudkinsky ...[et al.] // 2016.gada Zinātniskās konferences tēzes (Rīga, 2016.g. 17.-18.martā) / Rīgas Stradiņa universitāte. - Rīga, 2016. - 42.lpp.

Action of various wine polyphenols on starch hydrolysis / J.Krasilnikova, M.Zalomonson, A.Shulkin, A.Pycha // 2015.gada Zinātniskās konferences tēzes (Rīga, 2015.g. 26.-27.martā) / Rīgas Stradiņa universitāte. - Rīga, 2015. - 3.lpp.

Krasiļņikova, Jeļena. Effects of two type of red wines on the function of the digestive system / J.Krasilnikova, M.Zalomonson, A.Shulkin // Proceedings of the 4th International Conference on Food Digestion (Naples, Italy, March 17-19) : [Abstracts]. - Naples, 2015. - P.130.

Digestive system model under the influence of proanthocyanidins / J.Krasilnikova, G.Telysheva, T.Dizhbite ...[et al.] // 2014.gada Zinātniskās konferences tēzes (Rīga, 2014.g. 10.-11.aprīlī) / Rīgas Stradiņa universitāte. - Rīga, 2014. - 39.lpp.

Effect of proanthocyanidins on metabolic pathways and activity of Lipase : [abstract] / J.Krasilnikova, M.Zalomonson, A.Pycha ...[et al.] // Proceedings of the 3nd International Conference on Food Digestion (Wageningen, The Netherlands, March 11-13, 2014) / COST Action FA1005 INFOGEST. - Wageningen, 2014. - P.113.

Activation of pepsin by proanthocyanidins - rich compounds in vitro / J.Krasilnikova, G.Telysheva, T.Dizhbite ...[et al.] // 4th Management Committee & Working Group Meeting (Izmir, Turkey, Oct.8-10, 2013) : Book of abstracts / COST Action FA1005 INFOGEST. - Izmir, 2013. - P.29.

Activity of bark of European deciduous trees and their condensed tannins (proantocianidins) towards amylase in saliva : [abstract] / J.Krasilnikova, G.Telysheva, T.Dizhbite ...[et al.] // Proceedings of the 2nd International Conference on Food Digestion (Madrid, Spain, March 6-8, 2013) / COST Action FA1005 INFOGEST. - Madrid, 2013. - P.170.

The effect of extracted polyphenols from Pine, Goat Willow, Black Alder on amylase after physiological activation / J.Krasilnikova, M.Zalomonson, A.Pycha ...[et al.] // 2013.gada Zinātniskās konferences tēzes (Rīga, 2013.g. 21.-22.martā) / Rīgas Stradiņa universitāte. - Rīga, 2013. - 50.lpp.

Assessment of Lignin influence on saliva activity / J.Krasilnikova, L.Sedaghat, H.Müller-Werkmeister ...[et al.] // 2012.gada Zinātniskās konferences tēzes (Rīga, 2012.g. 29.-30.martā) / Rīgas Stradiņa universitāte. - Rīga, 2012. - 143.lpp.

Possibilities of lignin for metabolic syndrome pathogenesis correction on the pre-clinical stage / I.Krasilnikova, G.Telysheva, J.Ponomarenko ...[et al.] // 6th International Society of Antioxidants in Nutrition and health Congress on Polyphenols Applications (ISANH) (Paris, France, June 7-8, 2012) : [Abstracts]. - Paris, 2012. - P.69.

Propanol fraction of Lignin (JP-3, JP-4) action in gastric juice / J.Krasilnikova, J.Ponomarenko, F.Haunreiter ...[et al.] // 2012.gada Zinātniskās konferences tēzes (Rīga, 2012.g. 29.-30.martā) / Rīgas Stradiņa universitāte. - Rīga, 2012. - 144.lpp.

Rich-in-polyphenols grey alder bark extract as a potential component of functional food / I.Krasilnikova, G.Telysheva, T.Dizhbite ...[et al.] // 7th Baltic Conference on food science and technology "Innovative and healthy food for consumers" (FOODBALT-2012) (Kaunas, Lithuania, May 17-18, 2012) : Program and abstracts. - Kaunas, 2012. - P.58.

Two fractions of lignins - one way of action in blood / J.Krasilnikova, G.Telysheva, J.Ponomarenko ...[et al.] // Conference "Chemistry and target identification of natural products" (Bucharest, Romania, May 22-24, 2012) : [Abstracts]. - Bucharest, 2012. - P.49-50.

Effect of alder (alnus incana) diarylheptanoid oregonin on cardiomyophathy of different types / J.Krasilnikova, G.Telysheva, T.Dizhbite ...[et al.] // Myology 2011 : 4th International Congress of Myology (Lille, France, May 9-13, 2011) : Abstracts. - Lille, 2011. - P.49.

Influences of lignin polymer on the glucose in blood of patients with different types of obesity / J.Krasilnikova, L.Mikaelsson, L.Gasslander ...[et al.] // 2011.gada Zinātniskās konferences tēzes (Rīga, 2011.g. 14.-15.aprīlī) / Rīgas Stradiņa universitāte. - Rīga, 2011. - 198.lpp.

Diarylheptanoids and lignins : able and effective anti-aging natural compounds / I.Krasilnikova, G.Telysheva, T.Dizhbite ...[et al.] // Meeting on "Natural Products as Drugs and Leads for Drugs " (Kolymvari, Greece, Oct.12-15, 2010) : Abstracts. - Kolymvari, 2010. - P.70-71.

Total antioxidant status increasing in patients with SD-II after special relax transport course / J.Krasilnikova, A.Silova, I.Sergelis ...[et al.] // 2010.gada Zinātniskās konferences tēzes (Rīga, 2010.g. 18.-19.martā) / Rīgas Stradiņa universitāte. - Rīga, 2010. - 153.lpp.

Totālā antioksidatīvā statusa saturs dažādos uzturproduktos / J.Krasiļņikova, A.Silova, K.Krotova ...[u.c.] // 2010.gada Zinātniskās konferences tēzes (Rīga, 2010.g. 18.-19.martā) / Rīgas Stradiņa universitāte. - Rīga, 2010. - 48.lpp.

Books and brochures​​

Krasiļņikova, Jeļena. Biochemical aspects of some diseases : for RSU study programmes "Cell metabolism" and "Preclinical dysmetabolism" / J.Krasiļņikova ; Rīga Stradiņš University. Department of Human Physiology and Biochemistry. - Rīga : RSU, 2015. - 56 lpp.